Research Article
Mortality Predicted Accuracy for Hepatocellular Carcinoma Patients with Hepatic Resection Using Artificial Neural Network
Table 2
Comparison of clinical features between training data and validation data.
| Variables | Definitions | 1-year () | 3-year () | 5-year () | Training | Validation | | Training | Validation | | Training | Validation | | () | () | | () | () | | () | () | | | % | | % | | | % | | % | | | % | | % | |
| Age | ≦65 | 251 | 72.3 | 62 | 71.3 | 0.842 | 197 | 72.2 | 53 | 77.9 | 0.335 | 157 | 74.4 | 37 | 69.8 | 0.498 | >65 | 96 | 27.7 | 25 | 28.7 | | 76 | 27.8 | 15 | 22.1 | | 54 | 25.6 | 16 | 30.2 | | Gender | Male | 262 | 75.5 | 68 | 78.2 | 0.604 | 209 | 76.6 | 54 | 79.4 | 0.616 | 162 | 76.8 | 38 | 71.7 | 0.440 | Female | 85 | 24.5 | 19 | 21.8 | | 64 | 23.4 | 14 | 20.6 | | 49 | 23.2 | 15 | 28.3 | | Comorbidity | No | 170 | 49.0 | 39 | 44.8 | 0.487 | 144 | 52.7 | 35 | 51.5 | 0.850 | 112 | 53.1 | 31 | 58.5 | 0.480 | Yes | 177 | 51.0 | 48 | 55.2 | | 129 | 47.3 | 33 | 48.5 | | 99 | 46.9 | 22 | 41.5 | | Liver cirrhosis | No | 118 | 34.0 | 30 | 34.5 | 0.933 | 91 | 33.3 | 19 | 27.9 | 0.395 | 63 | 29.9 | 11 | 20.8 | 0.187 | Yes | 229 | 66.0 | 57 | 65.5 | | 182 | 66.7 | 49 | 72.1 | | 148 | 70.1 | 42 | 79.2 | | α-Fetoprotein (ng/mL) | ≦100 | 243 | 70.0 | 62 | 71.3 | 0.822 | 192 | 70.3 | 43 | 63.2 | 0.258 | 135 | 64.0 | 38 | 71.7 | 0.291 | >100 | 104 | 30.0 | 25 | 28.7 | | 81 | 29.7 | 25 | 36.8 | | 76 | 36.0 | 15 | 28.3 | | AST | ≦80 | 283 | 81.6 | 72 | 82.8 | 0.795 | 222 | 81.3 | 53 | 77.9 | 0.528 | 169 | 80.1 | 40 | 75.5 | 0.459 | >80 | 64 | 18.4 | 15 | 17.2 | | 51 | 18.7 | 15 | 22.1 | | 42 | 19.9 | 13 | 24.5 | | Total bilirubin | ≦1.0 | 255 | 73.5 | 57 | 65.5 | 0.139 | 200 | 73.3 | 52 | 76.5 | 0.590 | 152 | 72.0 | 41 | 77.4 | 0.435 | >1.0 | 92 | 26.5 | 30 | 34.5 | | 73 | 26.7 | 16 | 23.5 | | 59 | 28.0 | 12 | 22.6 | | Albumin | >3.5 | 270 | 77.8 | 68 | 78.2 | 0.944 | 210 | 76.9 | 52 | 76.5 | 0.937 | 153 | 72.5 | 39 | 73.6 | 0.875 | ≦3.5 | 77 | 22.2 | 19 | 21.8 | | 63 | 23.1 | 16 | 23.5 | | 58 | 27.5 | 14 | 26.4 | | BUN | ≦21 | 293 | 84.4 | 75 | 86.2 | 0.681 | 231 | 84.6 | 57 | 83.8 | 0.872 | 174 | 82.5 | 46 | 86.8 | 0.450 | >21 | 54 | 15.6 | 12 | 13.8 | | 42 | 15.4 | 11 | 16.2 | | 37 | 17.5 | 7 | 13.2 | | Platelet | >150 | 170 | 49.0 | 48 | 55.2 | 0.303 | 133 | 48.7 | 36 | 52.9 | 0.533 | 99 | 46.9 | 23 | 43.4 | 0.646 | ≦150 | 177 | 51.0 | 39 | 44.8 | | 140 | 51.3 | 32 | 47.1 | | 112 | 53.1 | 30 | 56.6 | | ASA classification | 1 | 87 | 25.1 | 19 | 21.8 | 0.616 | 75 | 27.5 | 21 | 30.9 | 0.599 | 63 | 29.9 | 23 | 43.4 | 0.149 | 2 | 179 | 51.6 | 50 | 57.5 | | 147 | 53.8 | 32 | 47.1 | | 106 | 50.2 | 23 | 43.4 | | 3, 4 | 81 | 23.3 | 18 | 20.7 | | 51 | 18.7 | 15 | 22.1 | | 42 | 19.9 | 7 | 13.2 | | Child-Pugh classification | A | 335 | 96.5 | 85 | 97.7 | 0.584 | 263 | 96.3 | 67 | 98.5 | 0.360 | 201 | 95.3 | 52 | 98.1 | 0.353 | B, C | 12 | 3.5 | 2 | 2.3 | | 10 | 3.7 | 1 | 1.5 | | 10 | 4.7 | 1 | 1.9 | | TNM stage | I | 190 | 54.8 | 49 | 56.3 | 0.444 | 142 | 52.0 | 29 | 42.6 | 0.374 | 93 | 44.1 | 26 | 49.1 | 0.095 | II | 119 | 34.3 | 25 | 28.7 | | 95 | 34.8 | 29 | 42.6 | | 86 | 40.8 | 14 | 26.4 | | IIIa, IIIb, IIIc, IV | 38 | 11.0 | 13 | 14.9 | | 36 | 13.2 | 10 | 14.7 | | 32 | 15.2 | 13 | 24.5 | | Tumor no. | Single | 238 | 68.6 | 63 | 72.4 | 0.489 | 190 | 69.6 | 39 | 57.4 | 0.054 | 127 | 60.2 | 38 | 71.7 | 0.122 | Multiple | 109 | 31.4 | 24 | 27.6 | | 83 | 30.4 | 29 | 42.6 | | 84 | 39.8 | 15 | 28.3 | | Tumor size (cm) | ≦5 | 268 | 77.2 | 67 | 77.0 | 0.965 | 204 | 74.7 | 50 | 73.5 | 0.840 | 154 | 73.0 | 37 | 69.8 | 0.644 | >5 | 79 | 22.8 | 20 | 23.0 | | 69 | 25.3 | 18 | 26.5 | | 57 | 27.0 | 16 | 30.2 | | Vascular invasion | No | 275 | 79.3 | 65 | 74.7 | 0.358 | 206 | 75.5 | 54 | 79.4 | 0.493 | 156 | 73.9 | 40 | 75.5 | 0.819 | Yes | 72 | 20.7 | 22 | 25.3 | | 67 | 24.5 | 14 | 20.6 | | 55 | 26.1 | 13 | 24.5 | | Portal vein invasion | No | 335 | 96.5 | 87 | 100 | 0.079 | 265 | 97.1 | 66 | 97.1 | 0.996 | 203 | 96.2 | 51 | 96.2 | 0.995 | Yes | 12 | 3.5 | 0 | 0.0 | | 8 | 2.9 | 2 | 2.9 | | 8 | 3.8 | 2 | 3.8 | | Surgical procedure | Laparoscopic | 69 | 19.9 | 15 | 17.2 | 0.577 | 51 | 18.7 | 16 | 23.5 | 0.368 | 51 | 24.2 | 10 | 18.9 | 0.413 | Open surgery | 278 | 80.1 | 72 | 82.8 | | 222 | 81.3 | 52 | 76.5 | | 160 | 75.8 | 43 | 81.1 | | Postoperative complication | No | 310 | 89.3 | 78 | 89.7 | 0.931 | 240 | 87.9 | 59 | 86.8 | 0.797 | 182 | 86.3 | 45 | 84.9 | 0.800 | Yes | 37 | 10.7 | 9 | 10.3 | | 33 | 12.1 | 9 | 13.2 | | 29 | 13.7 | 8 | 15.1 | | Recurrence | No | 158 | 45.5 | 37 | 42.5 | 0.614 | 115 | 42.1 | 23 | 33.8 | 0.212 | 71 | 33.6 | 17 | 32.1 | 0.828 | Yes | 189 | 54.5 | 50 | 57.5 | | 158 | 57.9 | 45 | 66.2 | | 140 | 66.4 | 36 | 67.9 | | Postoperative treatment | No | 156 | 45.0 | 35 | 40.2 | 0.427 | 104 | 38.1 | 27 | 39.7 | 0.807 | 67 | 31.8 | 19 | 35.8 | 0.570 | yes | 191 | 55.0 | 52 | 59.8 | | 169 | 61.9 | 41 | 60.3 | | 144 | 68.2 | 34 | 64.2 | | Status | Survived | 295 | 85 | 79 | 90.8 | 0.162 | 165 | 60.4 | 37 | 54.4 | 0.365 | 80 | 37.9 | 14 | 26.4 | 0.118 | Expired | 52 | 15 | 8 | 9.2 | | 108 | 39.6 | 31 | 45.6 | | 131 | 62.1 | 39 | 73.6 | |
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