Tumor Necrosis Factor-Alpha Gene Promoter Region Polymorphism and the Risk of Coronary Heart Disease

Table 2

Genotype and allele frequencies of the TNF-α gene −1031T>C and −863C>A polymorphisms in the study population.

TNF-𝛼 SNP	Controls (𝑛=310)	Patients (𝑛=310)	OR^†	95% CI^‡	P value^a
−1031T/C
TT	182 (58.71%)	178 (57.42%)	1.05	0.76–1.45	0.8
TC + CC	128 (41.29%)	132 (42.58%)
T	474 (76.45%)	462 (74.52%)	1.11	0.85–1.43	0.46
C	146 (23.55%)	158 (25.48%)
−863C/A
CC	201 (64.84%)	92 (29.68%)	4.37	3.11–6.12	<𝟎.𝟎𝟎𝟎𝟏^∗
CA + AA	109 (35.16%)	218 (70.32%)
C	503 (81.13%)	399 (64.35%)	2.38	1.83–3.08	<𝟎.𝟎𝟎𝟎𝟏^∗
A	117 (18.87%)	221 (35.65%)

Values are given in numbers and percentage.
aP value calculated by Chi-square test.
∗P value (<0.05) indicates statistical significance.
†Odds ratio.
‡95% confidence intervals.