The Antinociceptive and Anti-Inflammatory Activities of Aspidosperma tomentosum (Apocynaceae)

Table 1

Effect of extract, fractions, and isorhamnetin in the hot plate test.

Group	Pretreatment^†	Posttreatment^†
	0 min	30 min	60 min	90 min	120 min
Vehicle	4.2±0.7	3.7±0.7	3.7±0.6	3.7±0.7	4.7±1.2
Morphine	12.8±0.4^∗∗	10.3±0.8^∗∗	9.7±0.7^∗∗	9.7±0.9^∗∗	12.8±0.4^∗∗
CEE	4.3±0.5	4.8±1.8	6.6±1.2	5.9±1.4	6.3±0.9
Isorhamnetin	4.1±0.5	4.7±0.8	4.4±0.7	3.6±0.8	7.2±1.7
Soluble phase	4.6±0.7	5.0±0.7	4.6±0.8	3.1±0.4	2.9±0.5
Hexane 100%	3.2±0.7	2.6±0.4	3.0±0.4	2.8±0.5	3.1±0.6
Hex : CHCl3 50%	4.6±0.3	6.3±0.9	7.4±0.7^∗	7.0±1.5	7.3±1.3
CHCl3 100%	3.0±0.6	4.8±0.6	7.8±0.9^∗	5.3±0.2	6.3±1.5
CHCl3 : EtAcO 50%	3.9±0.7	4.3±0.7	3.6±0.4	3.3±0.8	3.9±0.8
EtAcO 100%	4.3±1.0	2.9±0.5	4.2±0.6	5.4±1.4	3.7±0.6
CHCl3 : MeOH 5%	3.2±0.8	8.5±1.2^∗∗	7.7±1.6^∗	6.7±1.7	7.2±1.1
CHCl3 : MeOH 10%	4.4±0.8	5.2±1.2	6.7±0.7	6.9±1.1	6.6±1.2

†Data represented as mean ± S.E.M. Number of animals = 8. *𝑃<0.05; **𝑃<0.01. (One-way ANOVA and Dunnett test.)