The Antinociceptive and Anti-Inflammatory Activities of Aspidosperma tomentosum (Apocynaceae)

Table 2

Effect of fractions Hex : CHCl₃ 50%, CHCl₃ 100%, and CHCl₃ : MeOH 5% in the hot plate test, in the presence of the drug nalaxone.

Group	Pretreatment^†	Posttreatment^†
	0 min	30 min	60 min	90 min	120 min
Vehicle	4.2±0.8	3.7±0.7	3.7±0.6	3.7±0.7	4.7±1.2
Morphine	5.9±0.3	12.8±0.4^∗∗	10.3±0.8^∗∗	9.7±0.7^∗∗	9.7±0.95^∗∗
Morphine + Nlx	2.6±0.5	3.3±0.9	3.8±0.7	2.6±0.8	3.0±0.4
Hex : CHCl3 50% + Nlx	2.6±0.3	3.7±0.5	1.2±0.2	3.6±0.8	2.4±0.4
CHCl3 100% + Nlx	2.6±0.4	4.2±0.5	2.0±0.4	3.2±0.6	2.7±0.3
CHCl3 : MeOH 5% + Nlx	3.2±0.2	3.9±0.8	3.0±0.7	3.3±0.5	5.0±1.2

†Data represented as mean ± S.E.M. Number of animals = 8. *𝑃<0.05; **𝑃<0.01. (One-way ANOVA and Dunnett test.)