Genotoxicity Assessment of Multispecies Probiotics Using Reverse Mutation, Mammalian Chromosomal Aberration, and Rodent Micronucleus Tests
Figure 2
The multispecies probiotic mixture does not provoke the frequency of chromosomal aberration (CA) in mammalian cell culture. (a) Three hour exposure to test substances followed by 17-hour recovery period. (b) Continuous 20-hour exposure to test substance. (c) Metabolic activation of test substance by cotreatment with S9 mix for 3-hours followed by 17-hour recovery period. AF: acentric fragment; MA: multiple aberrations; b: chromatid break; g: chromatid gap; R: ring; D: dicentric; B: chromosome break; G: chromosome gap.
