Table of Contents Author Guidelines Submit a Manuscript
The Scientific World Journal
Volume 2013, Article ID 282734, 5 pages
http://dx.doi.org/10.1155/2013/282734
Research Article

Chloroquine Inhibits Dengue Virus Type 2 Replication in Vero Cells but Not in C6/36 Cells

1Department of Internal Medicine, School of Medicine of Ribeirão Preto, University of São Paulo, 14049-900 Ribeirão Preto, SP, Brazil
2Program of Graduate Studies on Applied Microbiology and Immunology, School of Medicine of Ribeirão Preto, University of São Paulo, 14049-900 Ribeirão Preto, SP, Brazil

Received 30 November 2012; Accepted 23 December 2012

Academic Editors: V. H. Aquino and M. R. T. Nunes

Copyright © 2013 Kleber Juvenal Silva Farias et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [18 citations]

The following is the list of published articles that have cited the current article.

  • Parikesit, Kinanty, and Tambunan, “Screening of commercial cyclic peptides as inhibitor envelope protein dengue virus (DENV) through molecular docking and molecular dynamics,” Pakistan Journal of Biological Sciences, vol. 16, no. 24, pp. 1836–1848, 2013. View at Publisher · View at Google Scholar
  • Siwaporn Boonyasuppayakorn, Erin D. Reichert, Mark Manzano, Kuppuswamy Nagarajan, and Radhakrishnan Padmanabhan, “Amodiaquine, an antimalarial drug, inhibits dengue virus type 2 replication and infectivity,” Antiviral Research, vol. 106, pp. 125–134, 2014. View at Publisher · View at Google Scholar
  • Kleber Juvenal Silva Farias, Paula Renata Lima Machado, Renato Ferreira de Almeida Junior, Ana Alice de Aquino, and Benedito Antônio Lopes da Fonseca, “Chloroquine interferes with dengue-2 virus replication in U937 cells,” Microbiology and Immunology, vol. 58, no. 6, pp. 318–326, 2014. View at Publisher · View at Google Scholar
  • Hong-Wai Tham, Vinod R. M. T. Balasubramaniam, Bimo Ario Tejo, Hamdan Ahmad, and Sharifah Syed Hassan, “CPB1 of Aedes aegypti interacts with DENV2 E protein and regulates intracellular viral accumulation and release from midgut cells,” Viruses, vol. 6, no. 12, pp. 5028–5046, 2014. View at Publisher · View at Google Scholar
  • J. A. Tenreiro Machado, and Maria Eugenia Mata, “Analysis of World Economic Variables Using Multidimensional Scaling,” Plos One, vol. 10, no. 3, 2015. View at Publisher · View at Google Scholar
  • O. Ferraris, M. Moroso, O. Pernet, S. Emonet, A. Ferrier Rembert, G. Paranhos-Baccalà, and C.N. Peyrefitte, “Evaluation of Crimean-Congo hemorrhagic fever virus in vitro inhibition by chloroquine and chlorpromazine, two FDA approved molecules,” Antiviral Research, 2015. View at Publisher · View at Google Scholar
  • Ellie Kincaid, “A second look: Efforts to repurpose old drugs against Zika cast a wide net.,” Nature medicine, vol. 22, no. 8, pp. 824–5, 2016. View at Publisher · View at Google Scholar
  • Jianshe Lang, Daniel Vera, Yichen Cheng, and Hengli Tang, “Modeling Dengue Virus-Hepatic Cell Interactions Using Human Pluripotent Stem Cell-Derived Hepatocyte-like Cells,” Stem Cell Reports, 2016. View at Publisher · View at Google Scholar
  • Samson Sai-Yin Wong, Rosana Wing-Shan Poon, and Sally Cheuk-Ying Wong, “Zika virus infection—the next wave after dengue?,” Journal of the Formosan Medical Association, 2016. View at Publisher · View at Google Scholar
  • Rodrigo Delvecchio, Luiza Higa, Paula Pezzuto, Ana Valadão, Patrícia Garcez, Fábio Monteiro, Erick Loiola, André Dias, Fábio Silva, Matthew Aliota, Elizabeth Caine, Jorge Osorio, Maria Bellio, David O’Connor, Stevens Rehen, Renato de Aguiar, Andrea Savarino, Loraine Campanati, and Amilcar Tanuri, “Chloroquine, an Endocytosis Blocking Agent, Inhibits Zika Virus Infection in Different Cell Models,” Viruses, vol. 8, no. 12, pp. 322, 2016. View at Publisher · View at Google Scholar
  • Suzanne JF Kaptein, and Johan Neyts, “Towards antiviral therapies for treating dengue virus infections,” Current Opinion in Pharmacology, vol. 30, pp. 1–7, 2016. View at Publisher · View at Google Scholar
  • Hong-Tao Xu, Susan P. Colby-Germinario, Said Hassounah, Peter K. Quashie, Yingshan Han, Maureen Oliveira, Brent R. Stranix, and Mark A. Wainberg, “Identification of a Pyridoxine-Derived Small-Molecule Inhibitor Targeting Dengue Virus RNA-Dependent RNA Polymerase,” Antimicrobial Agents And Chemotherapy, vol. 60, no. 1, pp. 600–608, 2016. View at Publisher · View at Google Scholar
  • Alice R. de Oliveira, Philippe C. Mesquita, Paula R.L. Machado, Kleber J.S. Farias, Y?da M.B. de Almeida, Matheus F. Fernandes-Pedrosa, Alianda M. Corn?lio, Eryvaldo S?crates T. do Egito, and Arn?bio A. da Silva-J?nior, “Monitoring structural features, biocompatibility and biological efficacy of gamma-irradiated methotrexate-loaded spray-dried microparticles,” Materials Science and Engineering: C, 2017. View at Publisher · View at Google Scholar
  • Yu-Chih Lo, I-Hsiu Huang, Tzu-Chuan Ho, Yu-Wen Chien, and Guey Chuen Perng, “Antiviral Drugs and Other Therapeutic Options for Dengue Virus Infection,” Current Treatment Options in Infectious Diseases, 2017. View at Publisher · View at Google Scholar
  • Julie Dyall, Robin Gross, Jason Kindrachuk, Reed F. Johnson, Gene G. Olinger, Lisa E. Hensley, Matthew B. Frieman, and Peter B. Jahrling, “Middle East Respiratory Syndrome and Severe Acute Respiratory Syndrome: Current Therapeutic Options and Potential Targets for Novel Therapies,” Drugs, 2017. View at Publisher · View at Google Scholar
  • Md. Abdul Alim Al-Bari, “Targeting endosomal acidification by chloroquine analogs as a promising strategy for the treatment of emerging viral diseases,” Pharmacology Research & Perspectives, vol. 5, no. 1, pp. e00293, 2017. View at Publisher · View at Google Scholar
  • Shilu Malakar, Liji Sreelatha, Thanyaporn Dechtawewat, Sansanee Noisakran, Pa-thai Yenchitsomanus, Justin Jang Hann Chu, and Thawornchai Limjindaporn, “Drug repurposing of quinine as antiviral against dengue virus infection,” Virus Research, 2018. View at Publisher · View at Google Scholar
  • Satoru Watanabe, Jenny Guek-Hong Low, and Subhash G. Vasudevan, “Preclinical Antiviral Testing for Dengue Virus Infection in Mouse Models and Its Association with Clinical Studies,” ACS Infectious Diseases, 2018. View at Publisher · View at Google Scholar