The Scientific World Journal / 2013 / Article / Tab 7

Research Article

Evaluation of Genotoxic Effects of New Molecules with Possible Trypanocidal Activity for Chagas Disease Treatment

Table 7

Micronucleus test with RAW 264.7 macrophages using megazol analogs.

CompoundDose ( g/mL)‰ Mi.I.
± S.D.
% Apoptosis% Necrosis% Survival% Micronucleus ± S.D.

DMSO6.0 ± 4.20.060.1299.80.7 ± 0.4
PTAL 05-021.00.8 ± 0.0*5.90*0.1693.9*3.5 ± 1.2*
103.0 ± 2.27.14*0.0292.9*9.8 ± 6.4*
1001.2 ± 0.8*11.4*0.0688.5*6.6 ± 2.9*
PAMT 091.02.8 ± 1.62.680.0097.34.0 ± 4.7
101.2 ± 0.7*7.320.0692.62.7 ± 1.7*
1001.2 ± 1.7*24.7*0.2275.0*0.4 ± 0.2
PTAL 04-091.03.2 ± 2.41.50*0.0098.5*1.2 ± 0.8
101.2 ± 1.4*2.60*0.0097.4*3.8 ± 1.6*
1000.4 ± 1.4*10*0.0090.0*3.8 ± 1.9*
MNNG5.2 ± 3.70.300.0099.7*2.8 ± 1.4*

Percentage (%) and per mil (‰) mean and standard deviation (S.D.) of the ratio (samples/negative control) values of at least five experiments.
Negative control was DMSO; positive control was MNNG 0.5  M; Mi.I.: mitotic index; positive responses marked in bold when samples/negative control ratio ≥1.5. *Representation of a significant response ( ).

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