Plasma Homocysteine Is Associated with Increased Oxidative Stress and Antioxidant Enzyme Activity in Welders

Table 2

Vitamin B₆ status, oxidative stress indicators, glutathione, and antioxidant capacity.

Indicators	Welding exposure; (𝑛=57)	Nonexposure controls; (𝑛=42)
Vitamin B6 status
Plasma PLP (nmol/L)	75.48±72.23	71.16±91.77
<20 nmol/L (%)	0	0
Erythrocyte PLP (pmol/g Hb)	178.36±191.65	238.29±462.87
Plasma homocysteine (𝜇mol/L)	12.13±4.14	12.78±4.75
≥15 𝜇mol/L (𝑛, %)	11 (19.30%)	9 (21.43%)
Oxidative stress indicators
Malondialdehyde (𝜇M)	0.61±0.13	0.62±0.11
Oxidized low-density lipoprotein (mU/L)	30329.74±7507.95^a	27521.15±5891.29^b
8-oxo-7,8-dihydro-2′-deoxyguanosine; (ng/mg creatinine)	2.93±1.21	3.03±1.47
Antioxidant capacities
Total antioxidant capacity (𝜇mol/L)	4278.05±322.82	4280.41±246.07
Erythrocyte glutathione (𝜇mol/g Hb)	0.65±0.29^a	0.73±0.38^b
Erythrocyte SOD (U/g Hb)	8461.28±3202.72^a	13391.24±4729.43^b
Erythrocyte GPx (nmol/min/g Hb)	61858.44±15727.25	59021.55±16498.69
Erythrocyte GST (nmol/min/g Hb)	10306.87±6537.18	10943.85±4201.24

Values are means ± SD. PLP: pyridoxal 5′-phosphate; Hb: hemoglobin; SOD: superoxide dismutase; GPx: glutathione peroxidase; GST: glutathione S-transferase.
Values with different superscript letter are significantly different between two groups; 𝑃<0.05.