Plasma Homocysteine Is Associated with Increased Oxidative Stress and Antioxidant Enzyme Activity in Welders

Table 3

Spearman correlation of vitamin B₆ status and homocysteine with each indicator of oxidative stress and antioxidant capacity.

	Plasma PLP; (nmol/L)		Erythrocyte PLP; (pmol/g Hb)		Plasma homocysteine; (𝜇mol/L)
	𝑟𝑠
	Welding exposure	Nonexposure controls	Welding exposure	Nonexposure controls	Welding exposure	Nonexposure controls
Plasma homocysteine (𝜇mol/L)	−0.26*	−0.27	−0.51^†	−0.32*	—	—
Oxidative stress indicators
Malondialdehyde (𝜇M)	0.14	0.15	−0.09	−0.06	0.32*	0.14
Oxidized low-density lipoprotein (mU/L)	0.04	0.13	−0.06	−0.06	0.14	−0.19
8-oxo-7,8-dihydro-2′-deoxyguanosine (ng/mg creatinine)	−0.05	0.06	−0.04	0.08	−0.14	0.09
Antioxidant capacities
Total antioxidant capacity (𝜇M)	0.24	−0.02	0.08	−0.15	−0.18	0.23
Erythrocyte glutathione (𝜇mol/g Hb)	−0.04	0.04	0.11	−0.13	−0.09	0.36*
Superoxide dismutase (U/g Hb)	0.04	0.11	0.03	0.40**	0.34*	0.02
Glutathione peroxidase (nmol/min/g Hb)	−0.15	0.11	0.04	0.34*	−0.08	−0.23
Glutathione S-transferase (nmol/min/g Hb)	−0.11	−0.16	0.00	−0.15	−0.23	0.07

PLP: pyridoxal 5′-phosphate; Hb: hemoglobin. *𝑃<0.05. **𝑃<0.01. ^†𝑃<0.001.