Plasma Homocysteine Is Associated with Increased Oxidative Stress and Antioxidant Enzyme Activity in Welders

Table 4

Spearman partial correlation of vitamin B₆ status and homocysteine with each indicator of oxidative stress and antioxidant capacity.

	Plasma PLP; (nmol/L)		Erythrocyte PLP; (pmol/g Hb)		Plasma homocysteine; (𝜇mol/L)
	Partial 𝑟𝑠
	Welding exposure	Nonexposure controls	Welding exposure	Nonexposure controls	Welding exposure	Nonexposure controls
Plasma homocysteine (𝜇mol/L)	−0.44^†	−0.38*	−0.58^†	−0.18	—	—
Oxidative stress indicators
Malondialdehyde (𝜇M)	0.03	0.13	−0.16	0.13	0.15	−0.04
Oxidized low-density lipoprotein (mU/L)	0.04	0.25	−0.06	0.06	−0.04	−0.38*
8-oxo-7,8-dihydro-2′-deoxyguanosine (ng/mg creatinine)	−0.04	0.03	−0.08	0.22	−0.13	0.14
Antioxidant capacities
Total antioxidant capacity (𝜇M)	0.20	0.09	0.12	0.04	−0.34*	0.08
Erythrocyte glutathione (𝜇mol/g Hb)	−0.09	0.14	0.04	0.15	0.04	0.19
Superoxide dismutase (U/g Hb)	−0.13	0.10	−0.05	0.41*	0.29*	0.28
Glutathione peroxidase (nmol/min/g Hb)	−0.07	0.07	0.01	0.15	0.08	−0.05
Glutathione S-transferase (nmol/min/g Hb)	−0.14	−0.18	−0.01	−0.18	−0.11	0.06

PLP: pyridoxal 5′-phosphate; Hb: hemoglobin. Adjusting for age, gender, albumin, creatinine, smoking, drinking, and duration of employment. *𝑃<0.05. **𝑃<0.01. ^†𝑃<0.001.