Biological and Demographic Profile of Meningiomas in a Cohort of Egyptian Patients: Impact on Tumor Recurrence
Table 2
Prognostic accuracy of tumor size, PR expression, and necrosis compared to hazard rate among the 265 cases of meningioma studied.
Prognostic marker
AUC (95%CI)
P value
Cut-off value
Sn (95% CI)
Sp (95% CI)
+LR (95% CI)
−LR (95% CI)
PPV (95% CI)
NPV (95% CI)
Hazard rate from the model
0.878 (0.832 to 0.914)
<0.001
>0.0926
81.48 (61.9–93.7)
86.55 (81.6–90.6)
6.06 (4.2–8.8)
0.21 (0.10–0.5)
40.7 (27.4–55.1)
97.6 (94.6–99.2)
Tumor size
0.880 (0.835 to 0.917)
<0.001
>6
81.48 (61.9–93.7)
86.97 (82.0–91.0)
6.26 (4.3–9.1)
0.21 (0.10–0.5)
41.5 (28.0–56.0)
97.6 (94.6–99.2)
PR expression
0.703 (0.644 to 0.758)
<0.001
≤3
88.89 (70.8–97.6)
45.38 (38.9–51.9)
1.63 (1.4–1.9)
0.24 (0.08–0.7)
15.6 (10.2–22.3)
97.3 (92.3–99.4)
Necrosis*
40.74 (22.4–61.2)
83.61 (78.3–88.1)
2.49 (1.5–4.3)
0.71 (0.5–1.0)
22.0 (11.4–36.1)
92.6 (88.2–95.7)
ROC curve analysis was not performed for necrosis as it is a dichotomous variable. AUC: area under the curve; Sn: sensitivity; Sp: specificity; +LR: positive likelihood ratio; −LR: negative likelihood ratio; PPV: positive predictive value; NPV: negative predictive value.
