Research Article
Lack of Significant Association between Plasma/Serum miR-221 Expression and Poor Survival of Carcinoma: A Meta-Analysis
Table 1
Summary information of references included in the meta-analysis of miR-221 and survival.
| | Author | Year | Country | Study design | Type of carcinoma | Stage | Number of samples | Specimen | miR-221 assay | Cutoff | Survival analysis | Followup, months | Hazard ratios | CI | |
| |
Pu et al. [11] | 2010 | China | R | CRC | I–IV | 103 | Plasma | qRT-PCR | Youden index | OS | 60 | Reported
3.48 | 1.04–11.65 | 0.043 | |
Heegaard et al. [12] | 2012 | USA | R | NSCLC | I-II | 220 | Serum | qRT-PCR | median | OS | 60 | AP
0.63 | 0.40–1.01 | 0.053 | |
Heegaard et al. [12] | 2012 | USA | R | NSCLC | I-II | 220 | Plasma | qRT-PCR | median | OS | 60 | AP
0.92 | 0.59–1.45 | 0.723 | |
Li et al. [13] | 2011 | China | R | HCC | I–IV | 46 | Serum | qRT-PCR | 4.8-fold | OS | 60 | Reported
1.90 | 1.24–2.98 | 0.018 | |
Guo et al. [14] | 2010 | China | R | NTCL | I–IV | 79 | Plasma | qRT-PCR | Youden index | OS | 60 | Reported
0.18 | 0.06–0.56 | 0.003 |
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R: retrospective; CRC: colorectal cancer; NSCLC: nonsmall cell lung carcinoma; HCC: hepatocellular carcinoma; NTCL: NK/T-cell lymphoma; OS: overall survival; AP: author provided.
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