Table of Contents Author Guidelines Submit a Manuscript
The Scientific World Journal
Volume 2013, Article ID 394295, 11 pages
http://dx.doi.org/10.1155/2013/394295
Review Article

Ineffective Erythropoiesis in β-Thalassemia

1Centre National de la Recherche Scientifique-Unité Mixte de Recherche 8147, Université Paris V, René Descartes, Hôpital Necker, Paris, France
2Département de Biothérapie, Faculté de Médecine Paris Descartes, Sorbonne Paris-Cité et Assistance Publique—Hôpitaux de Paris, Hôpital Necker, Paris, France
3Fondation Imagine, Institut des Maladies Génétiques, Faculté de Médecine Paris Descartes, Sorbonne Paris-Cité et Assistance Publique—Hôpitaux de Paris, Hôpital Necker, Paris, France
4Laboratoire d'Excellence des Globules Rouges (GR-ex), Paris, France
5Fondation Imagine, Université Paris Descartes-Sorbonne Paris Cité, Paris, France
6Service de Médecine Interne, Faculté de Médecine Paris Descartes, Sorbonne Paris-Cité et Assistance Publique—Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Paris, France
7INSERM U 699, Hôpital Bichat, Université Paris Diderot, Paris, France
8Service d'Hématologie, Faculté de Médecine Paris Descartes, Sorbonne Paris-Cité et Assistance Publique—Hôpitaux de Paris Hôpital Necker, Paris, France

Received 28 December 2012; Accepted 3 February 2013

Academic Editors: Y. Al-Tonbary, M. A. Badr, A. El-Beshlawy, and F. Tricta

Copyright © 2013 Jean-Antoine Ribeil et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [43 citations]

The following is the list of published articles that have cited the current article.

  • Jean-Benoît Arlet, Jean-Antoine Ribeil, Flavia Guillem, Olivier Negre, Adonis Hazoume, Guillaume Marcion, Yves Beuzard, Michaël Dussiot, Ivan Cruz Moura, Samuel Demarest, Isaure Chauvot de Beauchêne, Zakia Belaid-Choucair, Margaux Sevin, Thiago Trovati Maciel, Christian Auclair, Philippe Leboulch, Stany Chretien, Luba Tchertanov, Véronique Baudin-Creuza, Renaud Seigneuric, Michaela Fontenay, Carmen Garrido, Olivier Hermine, and Geneviève Courtois, “HSP70 sequestration by free α-globin promotes ineffective erythropoiesis in β-thalassaemia,” Nature, 2014. View at Publisher · View at Google Scholar
  • Michael Dussiot, Thiago T. Maciel, Aurelie Fricot, Celine Chartier, Olivier Negre, Joel Veiga, Damien Grapton, Etienne Paubelle, Emmanuel Payen, Yves Beuzard, Philippe Leboulch, Jean-Antoine Ribeil, Jean-Benoit Arlet, Francine Cote, Genevieve Courtois, Yelena Z. Ginzburg, Thomas O. Daniel, Rajesh Chopra, Victoria Sung, Olivier Hermine, and Ivan C. Moura, “An activin receptor IIA ligand trap corrects ineffective erythropoiesis in beta-thalassemia,” Nature Medicine, vol. 20, no. 4, pp. 398–+, 2014. View at Publisher · View at Google Scholar
  • Bing Song, Yong Fan, Wenyin He, Detu Zhu, Xiaohua Niu, Ding Wang, Zhanhui Ou, Min Luo, and Xiaofang Sun, “Improved Hematopoietic Differentiation Efficiency of Gene-Corrected Beta-Thalassemia Induced Pluripotent Stem Cells by CRISPR/Cas9 System,” Stem Cells and Development, pp. 150205120749009, 2014. View at Publisher · View at Google Scholar
  • Antonella Isgrò, Daniele Armiento, Marco Andreani, Cristiano Gallucci, Cecilia Alfieri, Michela Ribersani, Javid Gaziev, Gioia De Angelis, Andrea Roveda, Manuela Testi, Guido Lucarelli, Pietro Sodani, Marco Marziali, Daniela Fraboni, and Katia Paciaroni, “Reduction of intramedullary apoptosis after stem cell transplantation in Black African variant of pediatric sickle cell anemia.,” Mediterranean Journal of Hematology and Infectious Diseases, vol. 6, no. 1, pp. 1–9, 2014. View at Publisher · View at Google Scholar
  • S Voskou, A Mutay, P Fanis, M Phylactides, and M Kleanthous, “Oxidative stress in B-thalassaemia and sickle cell disease,” Redox Biology, 2015. View at Publisher · View at Google Scholar
  • Alessandro Matte, Luigia De Falco, Achille Iolascon, Narla Mohandas, Xiuli An, Angela Siciliano, Christophe Leboeuf, Anne Janin, Mariasole Bruno, Soo Young Choi, Dae Won Kim, and Lucia De Franceschi, “The Interplay Between Peroxiredoxin-2 and Nuclear Factor-Erythroid 2 Is Important in Limiting Oxidative Mediated Dysfunction in β-Thalassemic Erythropoiesis,” Antioxidants & Redox Signaling, pp. 150714064853009, 2015. View at Publisher · View at Google Scholar
  • Sachith Mettananda, Richard J. Gibbons, and Douglas R. Higgs, “alpha-Globin as a molecular target in the treatment of beta-thalassemia,” Blood, vol. 125, no. 24, pp. 3694–3701, 2015. View at Publisher · View at Google Scholar
  • Zhengkui Zhou, Yu Jiang, Zheng Wang, Zhiheng Gou, Jun Lyu, Weiyu Li, Yanjun Yu, Liping Shu, Yingjun Zhao, Yanming Ma, Chao Fang, Yanting Shen, Tengfei Liu, Congcong Li, Qing Li, Mian Wu, Min Wang, Yunshuai Wu, Yang Dong, Wenting Wan, Xiao Wang, Zhaoli Ding, Yuedong Gao, Hui Xiang, Baoge Zhu, Suk-Ha Lee, Wen Wang, and Zhixi Tian, “Resequencing 302 wild and cultivated accessions identifies genes related to domestication and improvement in soybean,” Nature Biotechnology, 2015. View at Publisher · View at Google Scholar
  • Sachith Mettananda, Richard J. Gibbons, and Douglas R. Higgs, “Understanding α-globin gene regulation and implications for the treatment of β-thalassemia,” Annals of the New York Academy of Sciences, 2015. View at Publisher · View at Google Scholar
  • Ivan C. Moura, and Olivier Hermine, “Erythroferrone: the missing link in beta-thalassemia?,” Blood, vol. 126, no. 17, pp. 1974–+, 2015. View at Publisher · View at Google Scholar
  • Jean-Benoit Arlet, Jean-Antoine Ribeil, Flavia Guillem, Olivier Hermine, and Genevieve Courtois, “HSP70 regulates ineffective erythropoiesis in beta-thalassaemia,” M S-Medecine Sciences, vol. 31, no. 1, pp. 9–11, 2015. View at Publisher · View at Google Scholar
  • Afshan Sumera, Ammu Radhakrishnan, Abdul Aziz Baba, and Elizabeth George, “Review: Beta-thalassemia and molecular chaperones,” Blood Cells, Molecules, and Diseases, 2015. View at Publisher · View at Google Scholar
  • Astrid Glaser, Bradley McColl, and Jim Vadolas, “The therapeutic potential of genome editing for β-thalassemia,” F1000Research, vol. 4, 2015. View at Publisher · View at Google Scholar
  • Mahdi Ghatrehsamani, Masoud Soleimani, Behjat Al-Sadat Moayedi Esfahani, Mazdak Ganjalikhani Hakemi, Hedayatollah Shirzad, Nahid Eskandari, and Minoo Adib, “2,3,7,8-tetrachlorodibenzo-p-dioxin decrease expression of aryl hydrocarbon receptor in peripheral lymphocyte of β-thalassemia major patients.,” Advanced biomedical research, vol. 4, pp. 218, 2015. View at Publisher · View at Google Scholar
  • Dalina I. Tanyong, Prapaporn Panichob, Wasinee Kheansaard, and Suthat Fucharoen, “Effect of Tumor Necrosis Factor-Alpha on Erythropoietin-and Erythropoietin Receptor-Induced Erythroid Progenitor Cell Proliferation in beta-Thalassemi,” Turkish Journal Of Hematology, vol. 32, no. 4, pp. 304–310, 2015. View at Publisher · View at Google Scholar
  • Han Zhang, and Nami McCarty, “CRISPR-Cas9 technology and its application in haematological disorders,” British Journal of Haematology, 2016. View at Publisher · View at Google Scholar
  • Raymond Liang, and Saghi Ghaffari, “Advances in understanding the mechanisms of erythropoiesis in homeostasis and disease,” British Journal of Haematology, 2016. View at Publisher · View at Google Scholar
  • Jean-Benoît Arlet, Michaël Dussiot, Ivan C. Moura, Olivier Hermine, and Geneviève Courtois, “Novel players in β-thalassemia dyserythropoiesis and new therapeutic strategies,” Current Opinion in Hematology, vol. 23, no. 3, pp. 181–188, 2016. View at Publisher · View at Google Scholar
  • Cai-Li Wang, Li-Ping Liu, Li-Hong Han, Yan Su, Wen-Bin Qin, Li-Jun Gao, Ya-Qiong Gao, Cui-Feng Wang, Xiao-Yan Zhang, Bin Yan, and Gang Sun, “The effect of plasma components on hemoglobin release test in red blood cells (RBC),” Toxicological & Environmental Chemistry, pp. 1–12, 2016. View at Publisher · View at Google Scholar
  • Mehran Karimi, Parisa Jooya, Sezaneh Haghpanah, Maral Mokhtari, Narges Rezaei, Maede Fath, and Shirin Parand, “Evaluation of the Relationship Between Hb F Levels and Nucleated Red Blood Cells with Morbidity in Non Transfusion-Dependent Thalassemia Patients,” Hemoglobin, pp. 1–7, 2016. View at Publisher · View at Google Scholar
  • Paraskevi Rea Oikonomidou, Carla Casu, and Stefano Rivella, “New strategies to target iron metabolism for the treatment of beta thalassemia,” Annals of the New York Academy of Sciences, 2016. View at Publisher · View at Google Scholar
  • Awatef Mejri, Marwa Mansri, Sondess Hadj Fredj, Faida Ouali, Amina Bibi, Raouf Hafsia, Taieb Messaoud, and Hajer Siala, “ First description of the rs45496295 polymorphism of the C/EBPE gene in β-thalassemia intermedia patients ,” Hemoglobin, pp. 1–6, 2016. View at Publisher · View at Google Scholar
  • Jean-Benoît Arlet, Flavia Guillem, Mathilde Lamarque, Michael Dussiot, Thiago Maciel, Ivan Moura, Olivier Hermine, and Geneviève Courtois, “Protein-based therapeutic for anemia caused by dyserythropoiesis,” Expert Review of Proteomics, pp. 1–10, 2016. View at Publisher · View at Google Scholar
  • Marina Cavazzana, Jean-Antoine Ribeil, Chantal Lagresle-Peyrou, and Isabelle André-Schmutz, “Gene Therapy with Hematopoietic Stem Cells: The Diseased Bone Marrow's Point of View,” Stem Cells and Development, 2016. View at Publisher · View at Google Scholar
  • Abolhassan Ghaderi, Mohammad Reza Hafezi Ahmadi, Ehsan Hosseini, Ali Akbar Movasaghpour Akbari, Abbas Ali Hosein Pour Feyzi, Ataollah Hiradfar, and Majid Farshdousti Hagh, “Prevalence of the C282Y and H63D mutations of the HFE hemochromatosis gene in Azerian major β-thalassemia and iron overload,” Comparative Clinical Pathology, vol. 25, no. 1, pp. 151–154, 2016. View at Publisher · View at Google Scholar
  • Hadi Darvishi Khezri, Ebrahim Salehifar, Mehrnoush Kosaryan, Aily Aliasgharian, Hossein Jalali, and Arash Hadian Amree, “ Potential Effects of Silymarin and Its Flavonolignan Components in Patients with β -Thalassemia Major: A Comprehensive Review in 2015 ,” Advances in Pharmacological Sciences, vol. 2016, pp. 1–8, 2016. View at Publisher · View at Google Scholar
  • Melanie Franco, Michael Dussiot, Christian Rose, Yves Colin-Aronovicz, Olivier Hermine, Caroline Le Van Kim, Nelly Reihani, Jean-Benoit Arlet, Thierry Billette De Villemeur, and Nadia Belmatoug, “Unexpected macrophage-independent dyserythropoiesis in gaucher disease,” Haematologica, vol. 101, no. 12, pp. 1489–1498, 2016. View at Publisher · View at Google Scholar
  • Nikolaos Sousos, Despoina Adamidou, Philippos Klonizakis, Alexandra Agapidou, Stamatia Theodoridou, Georgios Spanos, Kyriakos Psarras, Evaggelia Vetsiou, Timoleon-Achilleas Vyzantiadis, and Efthymia Vlachaki, “Presence of the IVS-I-6-Mutated Allele in Beta-Thalassemia Major Patients Correlates with Extramedullary Hematopoiesis Incidence,” Acta Haematologica, pp. 175–182, 2017. View at Publisher · View at Google Scholar
  • Marina Cavazzana, Chiara Antoniani, and Annarita Miccio, “Gene Therapy for β-Hemoglobinopathies,” Molecular Therapy, 2017. View at Publisher · View at Google Scholar
  • Marina Cavazzana, “Innovations Needed for Effective Implementation of Ex Vivo Gene Therapies,” Frontiers in Medicine, vol. 4, 2017. View at Publisher · View at Google Scholar
  • Thomas R. L. Klei, Sanne M. Meinderts, Timo K. van den Berg, and Robin van Bruggen, “From the Cradle to the Grave: The Role of Macrophages in Erythropoiesis and Erythrophagocytosis,” Frontiers in Immunology, vol. 8, 2017. View at Publisher · View at Google Scholar
  • Naruchit Thanuthanakhun, Lalana Nuntakarn, Somponnat Sampattavanich, Usanarat Anurathapan, Suphanun Phuphanitcharoenkun, Savichaya Pornpaiboonstid, Suparerk Borwornpinyo, and Suradej Hongeng, “Investigation of FoxO3 dynamics during erythroblast development in β-thalassemia major,” Plos One, vol. 12, no. 11, pp. e0187610, 2017. View at Publisher · View at Google Scholar
  • Mehran Modares Sadeghi, Laleh Shariati, Zahra Hejazi, Mansoureh Shahbazi, Mohammad Amin Tabatabaiefar, and Hossein Khanahmad, “ Inducing indel mutation in the SOX6 gene by zinc finger nuclease for gamma reactivation: An approach towards gene therapy of beta thalassemia ,” Journal of Cellular Biochemistry, 2017. View at Publisher · View at Google Scholar
  • Paraskevi Rea Oikonomidou, and Stefano Rivella, “What can we learn from ineffective erythropoiesis in thalassemia?,” Blood Reviews, 2017. View at Publisher · View at Google Scholar
  • Hua-Ching Chang, Duen-Yi Huang, Mai-Szu Wu, Ching-Liang Chu, Shiang-Jong Tzeng, and Wan-Wan Lin, “Spleen tyrosine kinase mediates the actions of EPO and GM-CSF and coordinates with TGF-β in erythropoiesis,” Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2017. View at Publisher · View at Google Scholar
  • Thibaud Lefebvre, Sigismond Lasocki, Martine Fénéant-Thibault, Pierre-Jean Lamy, Séverine Cunat, Madeleine Ropert-Bouchet, Patricia Aguilar-Martinez, Sylvain Lehmann, and Constance Delaby, “Added value of hepcidin quantification for the diagnosis and follow-up of anemia-related diseases,” Annales de Biologie Clinique, vol. 75, no. 1, pp. 9–18, 2017. View at Publisher · View at Google Scholar
  • Eyayu Belay, Brian J. Hayes, C. Anthony Blau, and Beverly Torok-Storb, “Human Cord Blood and Bone Marrow CD34+ Cells Generate Macrophages That Support Erythroid Islands,” Plos One, vol. 12, no. 1, pp. e0171096, 2017. View at Publisher · View at Google Scholar
  • Ling-Li Li, Qi Li, Feng-Bo Zhang, and Yan-Lin Ma, “Gene therapy with induced pluripotent stem cells: A hope for beta thalassemia?,” Chinese Journal of Tissue Engineering Research, vol. 21, no. 9, pp. 1463–1469, 2017. View at Publisher · View at Google Scholar
  • Sachith Mettananda, “Thalassaemia: In a quest towards an ultimate cure,” Sri Lanka Journalof Child Health, vol. 46, no. 3, pp. 203–210, 2017. View at Publisher · View at Google Scholar
  • Rosi Bissinger, Abdulla Al Mamun Bhuyan, Syed M. Qadri, and Florian Lang, “Oxidative stress, eryptosis and anemia: a pivotal mechanistic nexus in systemic diseases,” The FEBS Journal, 2018. View at Publisher · View at Google Scholar
  • Laleh Shariati, Fattah Rohani, Nahid Heidari Hafshejani, Shirin Kouhpayeh, Maryam Boshtam, Mina Mirian, Ilnaz Rahimmanesh, Zahra Hejazi, Mehran Modarres, Ina Laura Pieper, and Hossein Khanahmad, “ Disruption of SOX6 gene using CRISPR/Cas9 technology for gamma-globin reactivation: An approach towards gene therapy of β-thalassemia ,” Journal of Cellular Biochemistry, 2018. View at Publisher · View at Google Scholar
  • Kat S. Moore, and Marieke von Lindern, “RNA Binding Proteins and Regulation of mRNA Translation in Erythropoiesis,” Frontiers in Physiology, vol. 9, 2018. View at Publisher · View at Google Scholar
  • Sachith Mettananda, and Douglas R. Higgs, “Molecular Basis and Genetic Modifiers of Thalassemia,” Hematology/Oncology Clinics of North America, vol. 32, no. 2, pp. 177–191, 2018. View at Publisher · View at Google Scholar