Optimization and Evaluation of Desloratadine Oral Strip: An Innovation in Paediatric Medication

Table 2

Saturated solubility studies of DSL (alone and in presence of poloxamers).

Composition	Solubility in PBS (mg/mL)
	N1	N2	N3	Mean	SD
DSL	3.21	3.43	3.09	3.24	0.17
DSL + P188 (0.5% w/v)	3.92	4.04	4.21	4.06	0.15
DSL + P188 (2.0% w/v)	4.11	4.26	4.3	4.22	0.10
DSL + P188 (4.0% w/v)	4.24	4.37	4.33	4.31	0.07
DSL + P407 (0.5% w/v)	3.74	3.96	3.82	3.84	0.11
DSL + P407 (2.0% w/v)	3.89	3.95	3.91	3.92	0.03
DSL + P407 (4.0% w/v)	4.2	4.27	4.35	4.27	0.08

N1, N2, and N3: replicate measurements; SD: Standard Deviation.