Effect of Vasoactive Intestinal Peptide (VIP) on NKG2D Signal Pathway and Its Contribution to Immune Escape of MKN45 Cells

Table 4

The cytotoxicity of VIP in 10⁻⁶ mol/L and its antagonist in 10⁻⁴ to 10⁻⁶ mol/L concentration for 48 h on the growth of NK cells to MKN45 cells.

Group	n	OD490
A: MKN45 + NK + VIP + antagonist (1 × 10^−4)	12	0.114±0.017^acd
B: MKN45 + NK + VIP + antagonist (1 × 10^−5)	12	0.115±0.018^acd
C: MKN45 + NK + VIP + antagonist (1 × 10^−6)	12	0.141±0.025^abce
D: MKN45 + antagonist (1 × 10^−4)	12	0.195±0.024^bde
E: MKN45 + antagonist (1 × 10^−5)	12	0.197±0.023^bde
F: MKN45 + antagonist (1 × 10^−6)	12	0.194±0.024^bde
G: MKN45 + NK + VIP	12	0.156±0.019^abc
H: MKN45 + VIP	12	0.196±0.027^b
I: MKN45 + NK	12	0.104±0.024^a
J: MKN45 (blank control)	12	0.208±0.027

𝐹=36.751, 𝑃<0.01. a stands for 𝑃<0.05 compared with group J. b stands for 𝑃<0.05 compared with group I. c stands for 𝑃<0.05 compared with group H. d stands for 𝑃<0.05 compared with group G. e stands for 𝑃<0.05 compared with group B.