Effect of Vasoactive Intestinal Peptide (VIP) on NKG2D Signal Pathway and Its Contribution to Immune Escape of MKN45 Cells

Table 5

The cytotoxicity of VIP or antagonist in 1 × 10⁻⁶ mol/L, 1 × 10⁻⁵ mol/L concentration, respectively, on the growth of NK cells to MKN45 cells for 24 h, 48 h, or 72 h.

Time (h)	n	OD490
		A	B	C	D	E	F
24	12	0.115±0.320	0.102±0.028	0.124±0.031	0.121±0.037	0.093±0.029	0.126±0.038
48	12	0.115±0.021^∗	0.153±0.017^∗△	0.197±0.015^△	0.200±0.028^△	0.106±0.016^∗	0.209±0.026^△
72	12	0.319±0.100^∗	0.381±0.109	0.375±0.097	0.381±0.120	0.346±0.124^∗	0.426±0.120^△

 *𝑃<0.05, compared with group F in same time. ^△𝑃<0.05, compared with group E in same time. Group A: MKN45 + NK + VIP + antagonist; group B: MKN45 + NK + VIP; group C: MKN45 + antagonist; group D: MKN45 + VIP; group E: MKN45 + NK; and group F: MKN45 (control).