PARP Inhibition Attenuates Histopathological Lesion in Ischemia/Reperfusion Renal Mouse Model after Cold Prolonged Ischemia

Table 1

Morphological and immunohistochemical comparison between control and IR C57BL/6 kidney mice samples.

	DPQ treated; control group; PARP-1^+/+	DPQ treated; IR (group 1)	P values; MW	Control group; PARP-1^+/+	IR (group 2)	P values; MW	Control group; PARP-1^0/0	IR (group 3); PARP-1^0/0	P values; MW
PARP-1 (mm^2)	548.64±303.19	320.42±475.34	0.026	784.57±353.95	1124.70±550.93	0.050	0.0±0.0	0.0±0.0	1
ATN	0.0±0.0	0.93±1.22	0.126	0.0±0.0	1.20±1.42	0.029	0.20±0.41	0.80±1.15	0.250
Sloughing tubular cells	0.60±0.51	0.73±0.458	0.539	0.0±0.0	0.87±0.35	0.000	0.07±0.26	0.80±0.68	0.004
Tubular vacuolization	0.40±0.51	0.64±0.16	0.740	0.27±0.59	1.13±0.52	0.000	0.27±0.46	0.53±0.52	0.217
Brush border loss	0.07±0.26	0.13±0.35	0.775	0.0±0.0	0.47±0.52	0.029	0.0±0.0	0.0±0.0	1
Tubular casts	0.20±0.41	0.27±0.46	0.775	0.0±0.0	0.73 ±0.60	0.001	0.13±0.35	0.40±0.51	0.217

MW: Mann-Whitney U-test, DPQ: 3,4-dihydro-5-[4-(1-piperidinyl)butoxyl]-1(2H)-isoquinolinone, IR: ischemia/reperfusion.