Table of Contents Author Guidelines Submit a Manuscript
The Scientific World Journal
Volume 2013, Article ID 489659, 6 pages
http://dx.doi.org/10.1155/2013/489659
Research Article

Effects of Resveratrol on Methotrexate-Induced Testicular Damage in Rats

1Department of Histology and Embryology, Faculty of Medicine, Karadeniz Technical University, 61080 Trabzon, Turkey
2Department of Medical Biochemistry, Faculty of Medicine, Karadeniz Technical University, 61080 Trabzon, Turkey
3Department of Emergency Medicine, Faculty of Medicine, Karadeniz Technical University, 61080 Trabzon, Turkey

Received 17 May 2013; Accepted 6 July 2013

Academic Editors: H. Grant and L. A. Videla

Copyright © 2013 Esin Yuluğ et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [27 citations]

The following is the list of published articles that have cited the current article.

  • Ensheng Xue, Jingjing Guo, Mei Huang, Yu Zhang, Shun Chen, and Rongxi Liang, “Effects of gradual low-flow reperfusion postconditioning on ischemia–reperfusion injury involving incomplete testicular torsion in rabbits,” Journal of Medical Ultrasonics, 2014. View at Publisher · View at Google Scholar
  • Azza A.K. El-Sheikh, Mohamed A. Morsy, and Abdulla Y. Al-Taher, “Multi-drug resistance protein (Mrp) 3 may be involved in resveratrol protection against methotrexate-induced testicular damage,” Life Sciences, 2014. View at Publisher · View at Google Scholar
  • María Mojica-Villegas, Jeannett Izquierdo-Vega, Germán Chamorro-Cevallos, and Manuel Sánchez-Gutiérrez, “Protective Effect of Resveratrol on Biomarkers of Oxidative Stress Induced by Iron/Ascorbate in Mouse Spermatozoa,” Nutrients, vol. 6, no. 2, pp. 489–503, 2014. View at Publisher · View at Google Scholar
  • Ebenezer Tunde Olayinka, and Ayokanmi Ore, “Kolaviron and L-Ascorbic Acid Attenuate Chlorambucil-Induced Testicular Oxidative Stress in Rats,” Journal of Toxicology, vol. 2014, pp. 1–9, 2014. View at Publisher · View at Google Scholar
  • Tingting Liu, He Qi, Long Ma, Zhaojun Liu, Huiling Fu, Wenzhen Zhu, Taiyu Song, Bingwu Yang, and Guorong Li, “ Resveratrol Attenuates Oxidative Stress and Extends Life Span in the Annual Fish Nothobranchius guentheri ,” Rejuvenation Research, pp. 150610074450006, 2015. View at Publisher · View at Google Scholar
  • Sibel Türedi, Esin Yuluğ, Ahmet Alver, Ömer Kutlu, and Cemil Kahraman, “Effects of resveratrol on doxorubicin induced testicular damage in rats,” Experimental and Toxicologic Pathology, vol. 67, no. 3, pp. 229–235, 2015. View at Publisher · View at Google Scholar
  • M. Kurus, A. Bay Karabulut, E. Taslidere, and O. Otlu, “Preventive effects of Resveratrol against azoxymethane-induced testis injury in rats,” Andrologia, 2016. View at Publisher · View at Google Scholar
  • K. Pratap Reddy, P. Madhu, and P. Sreenivasula Reddy, “Protective effects of resveratrol against cisplatin-induced testicular and epididymal toxicity in rats,” Food and Chemical Toxicology, 2016. View at Publisher · View at Google Scholar
  • Krishna Prahlad Maremanda, and G.B. Jena, “Methotrexate-induced germ cell toxicity and the important role of zinc and SOD1: Investigation of molecular mechanisms,” Biochemical and Biophysical Research Communications, 2016. View at Publisher · View at Google Scholar
  • Hai-Jie Ji, Dong-Mei Wang, Yu-Peng Wu, Yan-Yan Niu, Li-Li Jia, Bi-Wang Liu, Qian-Jin Feng, and Ma-Li Feng, “Wuzi Yanzong pill, a Chinese polyherbal formula, alleviates testicular damage in mice induced by ionizing radiation,” BMC Complementary and Alternative Medicine, vol. 16, no. 1, 2016. View at Publisher · View at Google Scholar
  • Aysun Sayılmaz, Aydan Özgörgülü, and Yasemin Yuyucu Karabulut, “The histopathological evaluation of healing effects of vitamin c administered before methotrexate therapy on testicular injury induced by methotrexate,” Turk Uroloji Dergisi, vol. 42, no. 4, pp. 235–239, 2016. View at Publisher · View at Google Scholar
  • Adalet Ozcicek, Nihal Cetin, Ferda Keskin Cimen, Levent Tumkaya, Ismail Malkoc, Mine Gulaboglu, Oguzhan Yarali, and Bahadir Suleyman, “The Impact of Resveratrol on Oxidative Stress Induced by Methotrexate in Rat Ileum Tissue: Evaluation of Biochemical and Histopathological Features an,” Medical Principles And Practice, vol. 25, no. 2, pp. 181–186, 2016. View at Publisher · View at Google Scholar
  • Aris Fakouri, Ahmad Asghari, Ghasem Akbari, and Pejman Mortazavi, “Effects of folic acid administration on testicular ischemia/reperfusion injury in rats,” Acta Cirurgica Brasileira, vol. 32, no. 9, pp. 755–766, 2017. View at Publisher · View at Google Scholar
  • Pavitra Ranawat, “Potential chemoprotective role of resveratrol against cisplatin induced testicular damage in mice,” Chemico-Biological Interactions, 2017. View at Publisher · View at Google Scholar
  • Erma Z. Drobnis, Ajay K. Nangia, Erma Z. Drobnis, and Ajay K. Nangia, “Immunosuppressants and Male Reproduction,” Impacts of Medications on Male Fertility, vol. 1034, pp. 179–210, 2017. View at Publisher · View at Google Scholar
  • Heba Al-Hussaini, and Narayana Kilarkaje, “Trans -resveratrol mitigates type 1 diabetes-induced oxidative DNA damage and accumulation of advanced glycation end products in glomeruli and tubules of rat kidneys,” Toxicology and Applied Pharmacology, 2017. View at Publisher · View at Google Scholar
  • Elif Guzel Meydanli, Asli Gumusel, Serbay Ozkan, Gamze Tanriverdi, M. B. Can Balci, Seval Develi Is, A. Ismet Hazar, Mujdat Uysal, and Seldag Bekpinar, “Effects of resveratrol on high-fructose-induced testis injury in rats,” Ultrastructural Pathology, pp. 1–9, 2017. View at Publisher · View at Google Scholar
  • Samy Makary, Mohamed Abdo, and Ereny Fekry, “Oxidative stress burden inhibits spermatogenesis in adult male rats: testosterone protective effect,” Canadian Journal of Physiology and Pharmacology, pp. 1–10, 2017. View at Publisher · View at Google Scholar
  • Heba Al-Hussaini, and Narayana Kilarkaje, “Effects of trans-resveratrol on type 1 diabetes-induced inhibition of retinoic acid metabolism pathway in retinal pigment epithelium of Dark Agouti rats,” European Journal of Pharmacology, vol. 834, pp. 142–151, 2018. View at Publisher · View at Google Scholar
  • Turan Yaman, Ahmet Uyar, Mehmet Salih Kaya, Ömer Faruk Keles, Baris Atalay Uslu, and Zabit Yener, “Protective effects of silymarin on methotrexate-induced damages in rat testes,” Brazilian Journal of Pharmaceutical Sciences, vol. 54, no. 1, 2018. View at Publisher · View at Google Scholar
  • Chong-Yang Li, Ya-Han Zhao, Hai-Sheng Hao, Hao-Yu Wang, Jin-Ming Huang, Chang-Liang Yan, Wei-Hua Du, Yun-Wei Pang, Pei-Pei Zhang, Yan Liu, Hua-Bin Zhu, and Xue-Ming Zhao, “Resveratrol significantly improves the fertilisation capacity of bovine sex-sorted semen by inhibiting apoptosis and lipid peroxidation,” Scientific Reports, vol. 8, no. 1, 2018. View at Publisher · View at Google Scholar
  • Heidar Heidari Khoei, Sajad Fakhri, Siavash Parvardeh, Zahra Shams Mofarahe, Zahra Baninameh, and Mina Vardiani, “Astaxanthin prevents the methotrexate-induced reproductive toxicity by targeting oxidative stress in male mice,” Toxin Reviews, pp. 1–7, 2018. View at Publisher · View at Google Scholar
  • D. Archana, Ch Supriya, B.P. Girish, B. Kishori, and P. Sreenivasula Reddy, “Alleviative effect of resveratrol on polyvinyl chloride-induced reproductive toxicity in male Wistar rats,” Food and Chemical Toxicology, 2018. View at Publisher · View at Google Scholar
  • C. Choux, M. Cavalieri, J. Barberet, M. Samson, B. Bonnotte, P. Fauque, and P. Sagot, “Traitements immunosuppresseurs et préservation de la fertilité : indications et modalités pratiques,” La Revue de Médecine Interne, 2018. View at Publisher · View at Google Scholar
  • R. Aslankoc, N. Gumral, M. Saygin, N. Senol, H. Asci, F. N. Cankara, and S. Comlekci, “The impact of electric fields on testis physiopathology, sperm parameters and DNA integrity-The role of resveratrol,” Andrologia, pp. e12971, 2018. View at Publisher · View at Google Scholar
  • Koc, Tekelıoglu, Takır, and Erısgın, “The effect of beta glucan on MTX induced testicular damage in rats,” Biotechnic and Histochemistry, pp. 1–6, 2018. View at Publisher · View at Google Scholar
  • Tümay Özgür, Neslihan Pınar, Gökhan Çakırca, and Mahir Kaplan, “The protective effects of alpha lipoic acid on methotrexate induced testis injury in rats,” Biomedicine and Pharmacotherapy, vol. 97, pp. 1486–1492, 2018. View at Publisher · View at Google Scholar