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The Scientific World Journal
Volume 2013, Article ID 519047, 10 pages
http://dx.doi.org/10.1155/2013/519047
Research Article

Blood Clot Simulation Model by Using the Bond-Graph Technique

CITEF, Universidad Politecnica de Madrid, C. Jose Gutierrez Abascal 2, 28006 Madrid, Spain

Received 2 August 2013; Accepted 19 September 2013

Academic Editors: H.-C. Han, M. Ohta, and A. Qiao

Copyright © 2013 Gregorio Romero et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The World Health Organization estimates that 17 million people die of cardiovascular disease, particularly heart attacks and strokes, every year. Most strokes are caused by a blood clot that occludes an artery in the cerebral circulation and the process concerning the removal of this obstruction involves catheterisation. The fundamental object of the presented study consists in determining and optimizing the necessary simulation model corresponding with the blood clot zone to be implemented jointly with other Mechanical Thrombectomy Device simulation models, which have become more widely used during the last decade. To do so, a multidomain technique is used to better explain the different aspects of the attachment to the artery wall and between the existing platelets, it being possible to obtain the mathematical equations that define the full model. For a better understanding, a consecutive approximation to the definitive model will be presented, analyzing the different problems found during the study. The final presented model considers an elastic characterization of the blood clot composition and the possibility of obtaining a consecutive detachment process from the artery wall. In conclusion, the presented model contains the necessary behaviour laws to be implemented in future blood clot simulation models.