Involvement of MAPKs and PLC Pathways in Modulation of Pacemaking Activity by So-Cheong-Ryong-Tang in Interstitial Cells of Cajal from Murine Small Intestine

Figure 2

Effects of 5-HT receptor subtype antagonists on SCRT-induced pacemaker potential responses in cultured ICCs. (a) SCRT (50 mg/mL) induced membrane depolarizations on ICCs. (b) Pacemaker potentials of ICCs exposed to SCRT (50 mg/mL) in the presence of 5-HT₃ receptor antagonist (Y25130; 10 μM). (c) Pacemaker potentials of ICCs exposed to SCRT in the presence of 5-HT₄ receptor antagonist (RS39604; 10 μM). (d) Pacemaker potentials of ICCs exposed to SCRT in the presence of 5-HT₇ receptor antagonist SB269970 (10 μM). Responses to SCRT in presence of different receptor antagonists are summarized in (e). Bars represent mean values ± SEs. ^∗∗𝑃<0.01. Significantly different from untreated controls. CTRL: Control.

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