Involvement of MAPKs and PLC Pathways in Modulation of Pacemaking Activity by So-Cheong-Ryong-Tang in Interstitial Cells of Cajal from Murine Small Intestine
Figure 6
Effects of various MAPK inhibitors on SCRT-induced pacemaker potentials responses in cultured ICCs. (a) SCRT (30 mg/mL) induced membrane depolarizations on ICCs. (b) Pacemaker potentials of cultured ICCs exposed to SCRT (30 mg/mL) in the presence of 10 μM of PD98059 (a p42/44 MAPK inhibitor). (c) Pacemaker potentials of cultured ICCs exposed to SCRT in the presence of 10 μM of SB203580 (a p38 MAPK inhibitor). (d) Pacemaker potentials of an ICC exposed to SCRT in the presence of 10 μM of JNK II inhibitor. Responses to SCRT in the presence of different MAPK inhibitors are summarized in (e). Bars represent mean values ± SEs. . Significantly different from untreated controls. CTRL: Control.
