Glutathione Redox System in β-Thalassemia/Hb E Patients

Table 2

Serum ferritin, glutathione concentration, redox ratio (GSH/GSSG), and GSH-related enzyme activities (GST, GR, GPx) of normal subjects and β-thalassemia/Hb E patients (mean ± SEM).

Subjects	Serum	Glutathione and GSH-related enzymes
	ferritin	Hb	Total GSH	GSH	GSSG	GSH/GSSG	GST	GR	GPx
	(pmol/L)	(g/L)	(µmol/L)	(µmol/L)	(µmol/L)		(U/mg Hb)	(U/mg Hb)	(U/g Hb)
Normal subjects (𝑛=27)	174±14	143.6±3.0	896.0±46.2	804.4±42.0	91.6±6.4	9.5±0.6	5.6±0.5	4.6±0.2	31.5±1.5
β-thalassemia/Hb E (𝑛=25)	3255±482	71.6±2.7	607.1±39.3	285.2±26.3	321.9±18.6	0.9±0.1	12.5±0.8	7.7±0.6	60.7±2.2
𝑃 value	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001
Splenectomized (𝑛=8)	5156±1112	70.6±6.3	487.2±54.0	198.2±48.6	288.9±26.3	0.7±0.1	10.4±1.6	8.9±1.2	58.8±4.6
Nonsplenectomized (𝑛=17)	2361±319	72.0±2.8	663.5±46.8	326.1±26.7	337.4±23.9	1.0±0.1	13.5±0.9	7.1±0.7	61.6±2.5
𝑃 value	0.004	0.817	0.033	0.020	0.231	0.024	0.079	0.186	0.577

GPx: glutathione peroxidase; GR: glutathione reductase; GSH: glutathione; GSSG: glutathione disulfide; GST: glutathione-S-transferase.