Associates of an Elevated Natriuretic Peptide Level in Stable Heart Failure Patients: Implications for Targeted Management
Table 2
Echocardiogram and collagen/inflammatory markers for total population and for population split by median BNP of 165 pg/mL.
All
Echocardiogram
EF (%)
0.004
E/e′
0.003
LAVI
0.007
LV wall stress
81 (58 : 116)
88 (64 : 122)
77 (59 : 103)
0.27
LVDD phase 1+
64 (69%)
31 (66%)
33 (72%)
0.70
Collagen markers
CITP (ug/L)
6.62 (5.12 : 9.24)
7.73 (5.42 : 10.53)
6.2 (4.82 : 8.13)
0.005
PICP (ng/L)
0.34 (0.25 : 0.46)
0.36 (0.27 : 0.5)
0.33 (0.23 : 0.44)
0.10
PINP (ug/L)
45.02 (37.25 : 51.2)
48 (41.65 : 55.1)
43.27 (32.86 : 47.83)
<0.001
PIIINP (ug/L)
4.72 (3.09 : 6.6)
5.35 (3.3 : 7.17)
4.09 (2.92 : 5.93)
0.014
Collagen turnover markers
TIMP-1 (μg/L )
0.28 (0.21 : 0.44)
0.32 (0.23 : 0.45)
0.25 (0.19 : 0.4)
0.010
MMP-9 (μg/L)
0.37 (0.22 : 0.58)
0.34 (0.2 : 0.54)
0.41 (0.24 : 0.6)
0.29
MMP-2 (μg/L)
2.33 (1.96 : 2.91)
2.55 (2.11 : 3)
2.15 (1.83 : 2.74)
0.004
Inflammatory markers
IL-6 (ng/mL)
9.61 (6.46 : 15.78)
10.27 (6.36 : 14.92)
9.12 (6.54 : 16.11)
0.76
IL-8 (ng/mL)
17.58 (12.08 : 27.27)
17.31 (11.89 : 26.45)
17.74 (12.17 : 28.45)
0.97
MCP-1 (ng/mL)
699 (429 : 961)
674 (422 : 922)
738 (460 : 1076)
0.16
TNFa (ng/mL)
3.89 (2.6 : 5.86)
3.96 (2.69 : 6.19)
3.87 (2.51 : 5.77)
0.53
Values are mean ± standard deviation or median (interquartile range); LAVI: left atrial volume index; LVDD: left ventricular diastolic dysfunction; EF: ejection fraction.
