Associates of an Elevated Natriuretic Peptide Level in Stable Heart Failure Patients: Implications for Targeted Management
Table 3
Multiple linear regression models of Log(BNP) for choice of inflammatory marker as IL8 and all combinations of collagen markers.
Parameter
PINP as collagen marker
PIIINP as collagen marker
CITP as collagen marker
PICP as Collagen Marker
Estimate (95% CI)
Estimate (95% CI)
Estimate (95% CI)
Estimate (95% CI)
Intercept
1.73 (0.54 : 2.93)
0.005
2.12 (0.99 : 3.24)
<0.001
2.31 (1.18 : 3.45)
<0.001
2.50 (1.36 : 3.65)
<0.001
Age
0.032 (0.017 : 0.046)
<0.001
0.032 (0.017 : 0.046)
<0.001
0.032 (0.017 : 0.046)
<0.001
0.033 (0.018 : 0.048)
<0.001
LVEF
−0.018 (−0.030 : −0.006)
0.003
−0.017 (−0.028 : −0.004)
0.006
−0.018 (−0.030 : −0.006)
0.003
−0.019 (−0.031 : −0.008)
0.001
Creatinine
0.0054 (0.0012 : 0.0095)
0.012
0.0044 (0.0002 : 0.0087)
0.042
0.0034 (−0.0012 : 0.0081)
0.146
0.0049 (0.0005 : 0.0093)
0.030
IL8
−0.0011 (0.0082 : 0.006)
0.759
−0.0035 (−0.010 : 0.003)
0.335
−0.002 (−0.009 : 0.004)
0.516
−0.0025 (−0.0097 : 0.0047)
0.495
Collagen
0.016 (0.005 : 0.026)
0.003
0.093 (0.029 : 0.157)
0.005
0.056 (0.007 : 0.106)
0.026
−0.0023 (−0.715 : 0.711)
0.995
E/e
′
0.047 (0.009 : 0.085)
0.016
0.046 (0.007 : 0.084)
0.019
0.048 (0.010 : 0.087)
0.015
0.051 (0.012 : 0.090)
0.010
Adjusted
0.34
0.34
0.32
0.30
LVEF: left ventricular ejection fraction; PINP: aminoterminal propeptide of procollagen type I; PIIINP: amino-terminal propeptide of procollagen type III; CITP: carboxy-terminal telopeptide of collagen type I; PICP: carboxyterminal propeptide of procollagen type I.
