Soluble RAGE Plasma Levels in Patients with Coronary Artery Disease and Peripheral Artery Disease

Table 1

Clinical characteristics and laboratory parameters of CAD patients with and without PAD and control subjects.

	CAD patients without PAD (𝑛=331)	CAD patients with PAD (𝑛=213)	Control subjects (𝑛=328)	𝑃 value
Age, y	64.1±5.97	64.5±10.7	63.3±8.3	Ns
Male, 𝑛 (%)	182 (79%)	175 (82%)	272 (83%)	Ns
BMI, kg/m^2	25.9±2.71	25.7±3.2	25.6±3.1	Ns
Ever-smoking, 𝑛 (%)	232 (70%)**	142 (67%)**	102 (31%)	𝑃<0.0001
Hypertension, 𝑛 (%)	202 (61%)**	164 (77%)**	58 (18%)	𝑃<0.0001
Diabetes, 𝑛 (%)	160 (33%)*	70 (32%)*	33 (10%)	𝑃<0.001
Total cholesterol, mmol/L	5.1±1	4.9±1.16	4.99±1.0	Ns
Triglycerides, mmol/L	3.19 (1.19–12.8)**	2.92 (0.83–9.6)*	1.47 (1.15–2.06)	𝑃<0.0001
HDL cholesterol, mmol/L	1.27±0.36	1.22±0.73	1.40±0.42	Ns
LDL cholesterol, mmol/L	3.17±0.87	3.39±1.23	3.26±1.2	Ns
C reactive protein, mg/dL	1.1 (0.6–1.6)*	1.3 (0.7–1.8)*	0.6 (0.3–1.1)	𝑃<0.01
sRAGE, pg/mL	766 (474–1226)***	615 (370–1158)**	1335 (936–1954)	𝑃<0.0001

^∗𝑃<0.05 versus controls; ^∗∗𝑃≤0.001 versus controls, ^∗∗∗𝑃<0.05 versus CAD patients with PAD.