Perspectives in Molecular Imaging Using Staging Biomarkers and Immunotherapies in Alzheimer’s Disease

Figure 4

Hypothetical model illustrating the synergic effect Aβ and Tau immunotherapies combined together could have on the delay predilection of age-at-onset in progressing throughout Alzheimer’s disease stages. The literature supports the notion that Aβ is not enough to treat AD symptoms, and recently tau immunotherapy may help in preventing cognitive decline in mouse AD model. This graph shows the effect each immunotherapy could have over time when giving at different pathological timelines (t1, t2, and t3). Excluding time-course, time-interval, and efficacy of Aβ and tau immunization might influence the outcome of neuropathological changes; both immunotherapies may show promise in delaying neurofibrillary tangles burden clearance into the brain, cognition decline, and clinical stages. Resulting code color glow circles are from t1 Aβ + t1 tau, t2 Aβ + t2 tau, and t3 Aβ + t3 tau, respectively.