A New Insight to Bone Turnover: Role of 𝝎-3 Polyunsaturated Fatty Acids

Figure 1

ROS-activated signalling pathways affecting the genesis of osteoblasts and osteoclasts. In osteoclast precursors, RANKL-induced activation of RANK stimulates ROS production, which is important for osteoclastogenesis. ROS-induced bone resorption occurs through the modulation of kinases and transcription factor activities in both osteoclasts and osteoblasts.