DNA Damage Sensor γ-H2AX Is Increased in Preneoplastic Lesions of Hepatocellular Carcinoma

Figure 2

γ-H2AX is significantly increased in preneoplastic lesions in the liver. (a) Representative images of immunostaining for γ-H2AX in non-HCC tissues. CH: chronic hepatitis; LC: liver cirrhosis; DN: dysplastic nodule (original magnification ×40). (b) Dot plots showing the γ-H2AX labeling index in normal livers (𝑛=5), chronic hepatitis (CH; 𝑛=18), liver cirrhosis (LC; 𝑛=22), dysplastic nodule (DN; 𝑛=19), and HCC (𝑛=58). Horizontal bars depict the mean value, and vertical bars indicate the standard deviation. 𝑎^∗∗: 𝑃 value of <0.01 versus normal livers; 𝑏^∗∗: 𝑃 value of <0.01 versus dysplastic nodule.

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