DNA Damage Sensor γ-H2AX Is Increased in Preneoplastic Lesions of Hepatocellular Carcinoma

Table 2

Associations of γ-H2AX with clinicopathological features in HCC.

Clinicopathological variables	γ-H2AX immunoreactivity
	Low; (𝑛=18)	High; (𝑛=40)	𝑃 value*
Age (year)
<50	2	4
≥50	16	36	0.613
Gender
male	15	34
female	3	6	0.576
Tumor size (cm)
<3	5	11
≥3	13	29	0.609
Intrahepatic metastasis
−	14	30
+	4	10	0.550
Venous invasion
−	16	37
+	2	3	0.497
Histological grade^†
I/II	10	35
III/IV	8	5	0.011*

†Histological grade was assessed according to the Edmondson-Steiner grade.
^∗𝑃 value of Chi² test.