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The Scientific World Journal
Volume 2013, Article ID 608415, 10 pages
http://dx.doi.org/10.1155/2013/608415
Research Article

Genetic Markers Associated to Dyslipidemia in HIV-Infected Individuals on HAART

1Serviço de Cardiologia, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, 90035-903 Porto Alegre, RS, Brazil
2Universidade Federal de Ciências da Saúde de Porto Alegre, Rua Sarmento Leite 245, Sala 309, 90050-170 Porto Alegre, RS, Brazil
3Serviço de Cardiologia, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Instituto de Avaliação de Tecnologias em Saúde, 90035-903 Porto Alegre, RS, Brazil
4Hospital Universitário Dr. Miguel Riet Correa Jr., 96200-000 Rio Grande, RS, Brazil
5Serviço de Assistência Especializada em HIV/AIDS, Universidade Federal de Pelotas, 96030-001 Pelotas, RS, Brazil
6Serviço de Medicina Interna, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, 90035-903 Porto Alegre, RS, Brazil

Received 31 July 2013; Accepted 28 August 2013

Academic Editors: S. C. Fuchs, M. B. Moreira, and B. Oyeledun

Copyright © 2013 Rosmeri K. Lazzaretti et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

This study evaluated the impact of 9 single nucleotide polymorphisms (SNPs) in 6 candidate genes (APOB, APOA5, APOE, APOC3, SCAP, and LDLR) over dyslipidemia in HIV-infected patients on stable antiretroviral therapy (ART) with undetectable viral loads. Blood samples were collected from 614 patients at reference services in the cities of Porto Alegre, Pelotas, and Rio Grande in Brazil. The SNPs were genotyped by conventional polymerase chain reaction (PCR) and real-time PCR. The prevalence of dyslipidemia was particularly high among the protease inhibitors-treated patients (79%). APOE (rs429358 and rs7412) genotypes and APOA5 −1131T>C (rs662799) were associated with plasma triglycerides (TG) and low-density-lipoprotein cholesterol levels (LDL-C). The APOA5 −1131T>C (rs662799) and SCAP 2386A>G (rs12487736) polymorphisms were significantly associated with high-density-lipoprotein cholesterol levels. The mean values of the total cholesterol and LDL-C levels were associated with both the APOB SP Ins/Del (rs17240441) and APOB XbaI (rs693) polymorphisms. In conclusion, our data support the importance of genetic factors in the determination of lipid levels in HIV-infected individuals. Due to the relatively high number of carriers of these risk variants, studies to verify treatment implications of genotyping before HAART initiation may be advisable to guide the selection of an appropriate antiretroviral therapy regimen.