Genetic Markers Associated to Dyslipidemia in HIV-Infected Individuals on HAART
Table 1
Genotypic and allelic frequencies of polymorphisms analyzed.
Polymorphisms
Genotypic frequency
Allelic frequency
APOA5 −1131T>C (rs662799)a
T
C
T/T
515 (84.7)
0.92
0.08
T/C
90 (14.8)
C/C
3 (0.5)
Total
608
APOA5 S19W (56C>G; rs3135506)a
C
G
C/C
500 (82)
0.90
0.10
C/G
103 (16.9)
G/G
7 (1.1)
Total
610
APOB SP Ins/Del (rs17240441)a
Ins
Del
Ins/ins
193 (47.3)
0.70
0.30
Ins/del
176 (43.1)
Del/del
39 (9.6)
Total
408
APOB XbaI, 7673C>T (rs693)a
C
T
C/C
122 (30)
0.55
0.45
C/T
203 (49.9)
T/T
82 (20.1)
Total
407
APOC3 3238C>G (rs5128)b
C
G
C/C
478 (78.8)
0.89
0.11
C/G
127 (20.9)
G/G
2 (0.3)
Total
607
APOE
a
E2
E3
E4
E2/E2
5 (0.8)
0.07
0.79
0.14
E2/E3
67 (11.2)
E2/E4
9 (1.5)
E3/E3
379 (63.6)
E3/E4
120 (20.1)
E4/E4
16 (2.7)
Total
596
LDLR intron 19G>T (rs6511720)a
G
T
G/G
487 (80.2)
0.90
0.10
G/T
113 (18.6)
T/T
7 (1.2)
Total
607
SCAP 2386A>G (rs12487736)a
A
G
A/A
168 (27.7)
0.52
0.48
A/G
296 (48.9)
G/G
142 (23.4)
Total
606
The difference in the number of individuals among single nucleotide polymorphisms (SNPs) is due to failure in genotyping some SNPs in the whole sample. Genotypic frequencies presented as number of patients (%).
a² test for Hardy-Weinberg equilibrium; .
b² test for Hardy-Weinberg equilibrium; .