Hypoxic Culture Conditions as a Solution for Mesenchymal Stem Cell Based Regenerative Therapy

Figure 4

Crosstalk between hypoxia and notch signaling, and regulation of stem cell proliferative gene expression. HIF: hypoxia-inducible factor; NEC: notch extracellular domain; NIC: notch intracellular domain; RBP: recombination-signal binding protein. (Modified from Gustafsson et al., (2005) [34] and Sainson and Harris (2006) [136]; see text for details).