Treatment of Pseudomonas and Staphylococcus Bronchopulmonary Infection in Patients with Cystic Fibrosis

Table 6

Summary of trials for eradication of MRSA.

Author	Study design	Subjects	Drug used	Outcomes	Main results
Solís et al. [31]	Retrospective	𝑁=12.; Age (median) = 117 months.; Inclusion criteria: CF with chronic MRSA infection	Continuous oral cephradine along with topical application of oral and nebulized vancomycin for 5 days	Microbiological and pulmonary function	MRSA was eradiated in 55%. FEV1 was not affected
Macfarlane et al. [32]	Prospective	𝑁=17.; Age = <18 years Inclusion criteria: CF with chronic MRSA infection	One five-day course of oral rifampicin and fusidic acid ± intravenous teicoplanin	Microbiological	MRSA was eradiated in 47% cases after the first course, in 71% after the second course, and in 94% when teicoplanin was added
Garske et al. [33]	Prospective study	𝑁=7.; Age (mean) = 29.3 years.; Inclusion criteria: adult CF patients with chronic MRSA infection	Rifampin and oral Fusidate for 6 months	Microbiological, use of iv antibiotics, and change of pulmonary function	MRSA was eradiated in 75%. Reduction in iv antibiotic use without any change in lung function
Halton et al. [34]	Prospective study	𝑁=17.; Age = <18 year.; Inclusion criteria: CF with chronic MRSA infection	TMP-SMX (Trimethoprim-Sulfamethoxazole) for 4 weeks, mupirocin and rifampin in the last week over 18-months	Microbiological	MRSA was eradiated in 60%
Vanderhelst et al. [35]	Prospective study	𝑁=11.; Age (median) = 9 years.; Inclusion criteria: CF with chronic MRSA infection	Rifampin and oral Fusidate along with topical mupirocin for 6 months	Microbiological	MRSA was eradiated in 100%