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The Scientific World Journal
Volume 2013 (2013), Article ID 649485, 6 pages
Research Article

Synthesis and Cytotoxicity of Chalcones and 5-Deoxyflavonoids

1College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China
2Department of Basic Medical, Changsha Medical University, Changsha 410082, China

Received 11 April 2013; Accepted 19 May 2013

Academic Editors: A. Guijarro, A. Nacci, B. Stanovnik, A. Tarraga, and A. D. Wastowski

Copyright © 2013 Jing Zhang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Chalcones 1~8 and 5-deoxyflavonoids 9~22 were synthesized in good yields by aldol condensation, Algar-Flynn-Oyamada reaction, glycosidation, and deacetylation reaction, respectively, starting from 2-acetyl phenols substituted by methoxy or methoxymethoxy group and appropriately benzaldehydes substituted by methoxy, methoxymethoxy group, or chlorine. Among them, 13 and 17~22 are new compounds. The cytotoxicity bioassays of these chalcones and 5-deoxyflavonoids were screened using the sulforhodamine B (SRB) protein staining method, and the results showed that compounds 2, 4, 5, 6, 10, 15, and 19 exhibited moderate cytotoxicity against the cancer cell line of MDA-MB-231, U251, BGC-823, and B16 in comparison with control drugs (HCPT, Vincristine, and Taxol).