Cardiotoxin III Inhibits Proliferation and Migration of Oral Cancer Cells through MAPK and MMP Signaling

Figure 3

The regulation of MMP-2 and -9 expressions by CTXIII.  Ca9-22 cells were treated with vehicle control, 3 and 5 𝜇g/mL of CTXIII for 24 h, respectively. Two major prometastasis associated extracellular matrix metalloproteinases MMP-2 and MMP-9 were examined using the Western blot assay. β-Actin was used as an internal control. Each representative blot was performed in at least triplication.