Research Article
Genetic Variants of Neurotransmitter-Related Genes and miRNAs in Egyptian Autistic Patients
Table 2
Allele frequencies MAOA uVNTR; MAOB rs1799836 and DRD2 Taq1A.
| | | Males | Females | | | Cases (%) | Controls (%) | OR (95% CI) | value | Cases (%) | Controls (%) | OR (95% CI) | value |
| | MAOA uVNTR | | | | | | | | | | Low expressing allele | 13 (33.3) | 6 (33.3) | 1 (0.31–3.27) | — | 12 (43) | 6 (25) | 2.25 (0.69–7.39) | 0.17 | | High expressing allele | 26 (66.7) | 12 (66 .7) | | | 16 (57) | 18 (75) | 0.044 (0.14–1.46) | | | Maternal MAOA uVNTR | | | | | | | | | | Low expressing allele | 21 (30) | 6 (25) | 1.29 (0.45–3.7) | 0.64 | 9 (35) | 6 (25) | 1.59 (0.47–5.42) | 0.46 | | High expressing allele | 49 (70) | 18 (75) | 0.78 (0.27–2.24) | | 17 (65) | 18 (75) | 0.63 (0.18–2.15) | | | MAOB rs1799836 | | | | | | | | | | G allele | 26 (66.7) | 1 (5.6) | 34 (4.06–284.347) | <0.001 | 20 (71) | 4 (17) | 12.5 (3.24–48.26) | <0.001 | | A allele | 13 (33.3) | 17 (94.4) | 0.03 (0.00–0.25) | | 8 (29) | 20 (83) | 0.08 (0.02–0.31) | |
| | | Patients | Mothers | | | Cases (%) | Controls (%) | OR (95% CI)
| P value | Cases (%) | Controls (%) | OR (95% CI) | P value |
| | DRD2 Taq1A | | | | | | | | | | A1 allele | 64 (60) | 29 (48) | 1.63 (0.86–3.09) | 0.13 | 25 (29) | 29 (48) | 0.44 (0.22–0.87) | 0.018 | | A2 allele | 42 (40) | 31 (52) | 0.61 (0.32–1.16) | | 61 (71) | 31 (52) | 2.28 (1.15–4.54) | |
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is significant; OR: odd ratio; 95%; CI: 95% confidence interval.
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