The Scientific World Journal

Research Article

Genome-Wide Analysis of DNA Methylation in Human Amnion

Table 3

Gene sets overrepresented among differentially methylated genes in amnion tissues from term (TNL, TL) and preterm (PTL) deliveries1.
TNL versus TL
Gene set2 -value3
HEART_DEVELOPMENT0.012
POSITIVE_REGULATION_OF_CYTOKINE_PRODUCTION0.017
GATED_CHANNEL_ACTIVITY0.024
REGULATION_OF_HEART_CONTRACTION0.041
REGULATION_OF_CYTOKINE_PRODUCTION0.044
TL versus PTL
NEGATIVE_REGULATION_OF_TRANSFERASE_ACTIVITY0.007
ADHERENS_JUNCTION40.011
HEPARIN_BINDING0.014
FOCAL_ADHESION_FORMATION0.02
FOCAL_ADHESION0.024
1Presented are the top 5 most significantly enriched gene sets from C5 collection (GO gene sets).
2Defined in the Molecular Signatures Database (MSigDB).
3The cutoff for statistical significance was .
4Also identified as being enriched ( ) in the analysis performed with the CP collection.
Abbreviations: TNL: term no labor; TL: term labor; PTL: preterm labor.