Research Article
New Urea and Thiourea Derivatives of Piperazine Doped with Febuxostat: Synthesis and Evaluation of Anti-TMV and Antimicrobial Activities
Table 4
Antimicrobial activity of the titled urea and thiourea derivatives 8(a–j).
| Compd. | Bacterial culture | Fungal culture | S. aureus | P. aeruginosa | E. coli | A. flavus | A. niger | C. albicans | ZOIc | MIC | ZOIa | MIC | ZOIa | MIC | ZOIa | MIC | ZOIa | MIC | ZOIa | MIC |
| 4 | 14.9 | 60 | 13.4 | 65 | 12.7 | 50 | 10.9 | 65 | 10.5 | 65 | 11.3 | 45 | 8a | 20.8 | 17 | 19.9 | 20 | 23.8 | 17 | 18.6 | 30 | 19.3 | 30 | 18.8 | 35 | 8b | 16.3 | 40 | 19.2 | 30 | 17.3 | 45 | 13.8 | 80 | 13.7 | 80 | 16.3 | 40 | 8c | 17.1 | 18 | 18.5 | 45 | 17.6 | 55 | 14.3 | 80 | 14.4 | 75 | 14.5 | 55 | 8d | 19.8 | 20 | 20.5 | 20 | 24.7 | 15 | 19.9 | 20 | 19.6 | 30 | 19.8 | 20 | 8e | 18.9 | 30 | 20.8 | 20 | 19.4 | 35 | 17.5 | 45 | 16.8 | 65 | 17.7 | 30 | 8f | 20.1 | 15 | 19.8 | 25 | 20.5 | 30 | 19.2 | 20 | 20.1 | 20 | 19.3 | 25 | 8g | 17.8 | 45 | 17.3 | 35 | 18.3 | 70 | 16.4 | 50 | 17.8 | 40 | 16.4 | 30 | 8h | 16.1 | 40 | 16.2 | 35 | 15.2 | 70 | 13.9 | 80 | 14.5 | 70 | 13.8 | 80 | 8i | 16.7 | 30 | 18.8 | 40 | 17.9 | 45 | 16.1 | 45 | 18.3 | 35 | 15.9 | 70 | 8j | 19.7 | 25 | 20.8 | 20 | 22.8 | 20 | 19.0 | 25 | 19.6 | 25 | 19.7 | 20 | Ciprofloxacin | 22 | 04 | 23 | 05 | 27 | 04 | — | — | — | — | — | — | Fluconazole | — | — | — | — | — | — | 21 | 04 | 23 | 04 | 22 | 05 |
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ZOI: zone of inhibition in mm.
cConcentration of compounds at 200 µg/mL.
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