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The Scientific World Journal
Volume 2013, Article ID 702929, 4 pages
Research Article

One-Pot Synthesis of 2′-Aminobenzothiazolo-Arylmethyl-2-Naphthols Catalyzed by NBS under Solvent-Free Conditions

1Department of Medicinal Chemistry, Pharmacy College of Xinxiang Medical University, Xinxiang 453003, China
2Department of Gynecological and Obstetric, The Third Affiliated Hospital of Xinxiang Medical College, Xinxiang 453003, China

Received 6 April 2013; Accepted 13 May 2013

Academic Editors: F. A. Attaby, A. Sacchetti, and A. K. Saikia

Copyright © 2013 Wei Lin Li et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


To develop a new facile protocol for the synthesis of 2′-aminobenzothiazolo-arylmethyl-2-naphthol derivatives, N-bromosuccinimide (NBS) was used as an efficient catalyst for the one-pot synthesis of 2′-aminobenzothiazolo-arylmethyl-2-naphthols in excellent yields from β-naphthol (1 mmol), aromatic aldehydes (1 mmol), and 2-aminobenzothiazole (1 mmol) at 60°C under solvent-free conditions.