Autism in Preschoolers: Does Individual Clinician’s First Visit Diagnosis Agree with Final Comprehensive Diagnosis?
Table 1
Sensitivity, specificity, and agreement of measurements between assessments and clinical diagnosis (all subjects).
Assessment
Sensitivity ASD clinical diagnosis (95% CI)
Specificity ASD clinical diagnosis (95% CI)
Weighted kappa (95% CI)
(%) agreement
Clinical diagnosis more ASD
Clinical diagnosis less ASD
value systematic changes between raters and clinical diagnosis
Medical/neurologic-psychiatric
0.64 (0.43; 0.82)
0.89 (0.52; 1.00)
0.40 (0.17–0.64)
21 (62%)
9 (26%)
4 (12%)
0.2668
DQ
0.40 (0.21; 0.61)
1.00 (0.66; 1.00)
0.28 (0.09–0.47)
16 (47%)
15 (44%)
3 (9%)
0.0075
Language
0.63 (0.41; 0.81)
0.78 (0.40; 0.97)
0.33 (0.08–0.59)
19 (58%)
9 (27%)
5 (15%)
0.4240
DISCO (parent interview)
0.74 (0.52; 0.90)
0.89 (0.52; 1.00)
0.40 (0.20–0.59)
20 (63 %)
7 (22%)
5 (16%)
0.7744
ADOS
0.60 (0.39; 0.79)
1.00 (0.66; 1.00)
0.43 (0.21–0.64)
21 (62%)
10 (29%)
3 (9%)
0.0923
Preschool/home
0.68 (0.46; 0.85)
0.89 (0.52; 1.00)
0.44 (0.18–0.69)
23 (68%)
8 (24%)
3 (9%)
0.2266
The sensitivity and specificity are calculated on the dichotomous variables ASD/no ASD, where “no ASD” also contains the classification “probably/possible ASD.” Weighted kappa, % agreement, clinical diagnosis more ASD, clinical diagnosis less ASD, and value are all calculated at the 3-point division; ASD, ASD probable/possible; and no ASD.
