The Scientific World Journal / 2013 / Article / Tab 1

Research Article

Alum Catalyzed Simple, Efficient, and Green Synthesis of 2-[3-Amino-5-methyl-5-(pyridin-3-yl)-1,5-dihydro-4H-1,2,4-triazol-4-yl]propanoic Acid Derivatives in Aqueous Media

Table 1

Physical characterization data of compounds (5a–i) and (9a).

EntryR1ProductsTime (hrs)Yield (%)MP (°C)

5a−CH3716389.table.001a690200
5b−CH2COOH716389.table.001b787205
5c−CH2(CH3)
CH2CH3
716389.table.001c787194
5d716389.table.001d716389.table.001e888174
5e−CH2CH2SCH3716389.table.001f690185
5f−CH2C6H5716389.table.001g788182
5g−CH2OH716389.table.001h689198
5h716389.table.001i716389.table.001j686197
5iCH2(CH3)2716389.table.001k787183
9a716389.table.001l788190

Reaction Conditions: All the compounds were synthesized by stirring 3-acetyl pyridine 1 (2 mmol), amino acid 2 (2 mmol), thiosemicarbazide (2 mmol), and alum (25 mol%) in water (25 mL) at 80°C for 6-7 hrs.

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