The Scientific World Journal / 2013 / Article / Tab 2

Review Article

Optimization of Drug Delivery Systems for Intraperitoneal Therapy to Extend the Residence Time of the Chemotherapeutic Agent

Table 2

Advantages and disadvantages of the drug delivery systems investigated for IP therapy.

Drug delivery systemAdvantagesDisadvantages

MicrospheresProlonged retention timeLimited tumor penetration
Risk of peritoneal adhesions
NanoparticlesSmall size passive targeting
Avoiding MDR
Lower incidence of peritoneal adhesions
Rapid clearance out of the abdominal cavity
LiposomesSimilar to nanoparticles
Active targeting by varying parameters
Similar to nanoparticles
MicellesProlonged retention time Increasing systemic toxicity
Injectable systemsProlonged retention time
Localized and sustained drug delivery
Lower systemic toxicity
Prevention against peritoneal adhesion
Viscosity issues
Implantable systemsSimilar to injectable systemsInvasive
Surgical expertise

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