Islet-1 Immunoreactivity in the Developing Retina of Xenopus laevis
Morphological features and expression patterns of Isl1 and other cell differentiation markers in the St35/36 Xenopus laevis retina. (a) Toluidine blue-stained transverse retinal resin sections showed that neural retina remained undifferentiated during this stage. (b) Although no plexiform layers were observed, many Isl1-positive nuclei were mainly located near the inner surface of the neuroretina. (c) Immunoreactive ganglion cell axons for SV2 were observed in the vitreal surface of the retina (asterisks). Furthermore, immunoreactivity was also detected near the scleral surface of the undifferentiated retina (arrowheads). (d)–(f) CERN-922 antibody revealed that sparse photoreceptors were differentiating by this stage in the scleral surface of the central nonlayered retina ((d), (F)). L: lens; NbL: neuroblastic layer. Scale bars: 50 μm.
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