18F-Fluorothymidine-Pet Imaging of Glioblastoma Multiforme: Effects of Radiation Therapy on Radiotracer Uptake and Molecular Biomarker Patterns
Figure 7
Decreased 18F-FLT uptake corresponds with regions of hypoxia and angiogenesis. (a) Comparison of axial and coronal views 18F-FLT-PET imaging sections in control flank tumors and immunohistochemical (IHC) and immunofluorescent (IF) staining with DAPI for vascular endothelial growth factor (VEGF) and hypoxia induction factor 1 alpha (HIF-). Positive VEGF and HIF- (red) with reduced DAPI (blue) is noted (white and red arrows). (b) Comparison of 18F-FLT-PET imaging sections and corresponding IHC and IF staining in flank tumors 2 weeks after 16 Gy RT as performed in (a). Positive tumor VEGF and HIF- expression with DAPI signaling are noted (white and red arrows).
