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The Scientific World Journal
Volume 2013 (2013), Article ID 808460, 5 pages
http://dx.doi.org/10.1155/2013/808460
Research Article

Borneol, a Bicyclic Monoterpene Alcohol, Reduces Nociceptive Behavior and Inflammatory Response in Mice

1Núcleo de Estudos e Pesquisas de Plantas Medicinais, Universidade Federal do Vale do São Francisco, 56.304-205 Petrolina, PE, Brazil
2Laboratório de Farmacologia Pré-Clínica, Universidade Federal de Sergipe, 49.000-100 São Cristóvão, SE, Brazil
3Departamento de Farmácia, Universidade Federal de Sergipe,49.000-100 São Cristóvão, SE, Brazil

Received 17 February 2013; Accepted 8 March 2013

Academic Editors: N. J. Christensen and M. W. Jann

Copyright © 2013 Jackson Roberto Guedes da Silva Almeida et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Borneol, a bicyclic monoterpene, has been evaluated for antinociceptive and anti-inflammatory activities. Antinociceptive and anti-inflammatory activities were studied by measuring nociception by acetic acid, formalin, hot plate, and grip strength tests, while inflammation was prompted by carrageenan-induced peritonitis. The rotarod test was used to evaluate motor coordination. Borneol produced a significant ( ) reduction of the nociceptive behavior at the early and late phases of paw licking and reduced the writhing reflex in mice (formalin and writhing tests, resp.). When the hot plate test was conducted, borneol (in higher dose) produced an inhibition ( ) of the nociceptive behavior. Such results were unlikely to be provoked by motor abnormality. Additionally, borneol-treated mice reduced the carrageenan-induced leukocytes migration to the peritoneal cavity. Together, our results suggest that borneol possess significant central and peripheral antinociceptive activity; it has also anti-inflammatory activity. In addition, borneol did not impair motor coordination.