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The Scientific World Journal
Volume 2013, Article ID 809891, 13 pages
http://dx.doi.org/10.1155/2013/809891
Research Article

Therapeutic Doses of Nonsteroidal Anti-Inflammatory Drugs Inhibit Osteosarcoma MG-63 Osteoblast-Like Cells Maturation, Viability, and Biomineralization Potential

1Department of Nursing, Faculty of Health Sciences, University of Granada, Avenida Madrid s/n, 18071 Granada, Spain
2School of Pharmacy & Biomolecular Science, University of Brighton, Huxlye Building, Moulsecoomb, Brighton BN2 4G1, UK
3Institute of Neurosciences, Faculty of Medicine, University of Granada, Granada Health-Science Technology Park, 18100 Armilla, Granada, Spain

Received 28 June 2013; Accepted 14 August 2013

Academic Editors: M. W. Jann and Y. Shigeri

Copyright © 2013 E. De Luna-Bertos et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [13 citations]

The following is the list of published articles that have cited the current article.

  • Zhi Li, Youjun Li, Nan Wang, Lifeng Yang, Wei Zhao, and Xiandong Zeng, “Establishment and analysis of osteosarcoma cell sublines with different metastatic characteristics.,” Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, vol. 35, no. 9, pp. 8591–6, 2014. View at Publisher · View at Google Scholar
  • Rosa Medina-Huertas, Francisco Javier Manzano-Moreno, Elvira De Luna-Bertos, Javier Ramos-Torrecillas, Olga Garcia-Martinez, and Concepcion Ruiz, “The effects of low-level diode laser irradiation on differentiation, antigenic profile, and phagocytic capacity of osteoblast-like cells (MG-63),” Lasers in Medical Science, vol. 29, no. 4, pp. 1479–1484, 2014. View at Publisher · View at Google Scholar
  • Francisco Javier Manzano-Moreno, Javier Ramos-Torrecillas, Elvira De Luna Bertos, Concepción Ruiz, and Olga García-Martínez, “High doses of bisphosphonates reduce osteoblast-like cell proliferation by arresting the cell cycle and inducing apoptosis,” Journal of Cranio-Maxillofacial Surgery, 2014. View at Publisher · View at Google Scholar
  • Francisco Javier Manzano-Moreno, Javier Ramos-Torrecillas, Elvira De Luna-Bertos, Candela Reyes-Botella, Concepcion Ruiz, and Olga Garcia-Martinez, “Nitrogen-containing bisphosphonates modulate the antigenic profile and inhibit the maturation and biomineralization potential of osteoblast-like cells,” Clinical Oral Investigations, vol. 19, no. 4, pp. 895–902, 2015. View at Publisher · View at Google Scholar
  • Dan Liao, Li Zhong, Tingmei Duan, Ru-Hua Zhang, Xin Wang, Gang Wang, Kaishun Hu, Xiaobin Lv, and Tiebang Kang, “Aspirin Suppresses the Growth and Metastasis of Osteosarcoma through the NF-kappa B Pathway,” Clinical Cancer Research, vol. 21, no. 23, pp. 5349–5359, 2015. View at Publisher · View at Google Scholar
  • O. García-Martínez, E. De Luna-Bertos, J. Ramos-Torrecillas, F.J. Manzano-Moreno, and C. Ruiz, “Repercussions of NSAIDS drugs on bone tissue: The osteoblast,” Life Sciences, 2015. View at Publisher · View at Google Scholar
  • Francisco Javier Manzano-Moreno, Javier Ramos-Torrecillas, Elvira De Luna-Bertos, Candela Reyes-Botella, Olga García-Martínez, and Concepción Ruiz, “The Effect of Clodronate on Antigenic Profile, Growth and Differentiation of Osteoblast-Like Cells,” Journal of Oral and Maxillofacial Surgery, 2016. View at Publisher · View at Google Scholar
  • Olga Garcia-Martinez, Elvira De Luna-Bertos, Javier Ramos-Torrecillas, Concepcion Ruiz, Egle Milia, Maria Luisa Lorenzo, Brigida Jimenez, Araceli Sanchez-Ortiz, and Ana Rivas, “Phenolic Compounds in Extra Virgin Olive Oil Stimulate Human Osteoblastic Cell Proliferation,” Plos One, vol. 11, no. 3, 2016. View at Publisher · View at Google Scholar
  • G. Lucena, C. Reyes-Botella, O. García-Martínez, J. Ramos-Torrecillas, E. De Luna Bertos, and C. Ruiz, “Effect of NSAIDs on the aminopeptidase activity of cultured human osteoblasts,” Molecular and Cellular Endocrinology, 2016. View at Publisher · View at Google Scholar
  • Lucia Melguizo-Rodríguez, Víctor J. Costela-Ruiz, Francisco J. Manzano-Moreno, Rebeca Illescas-Montes, Javier Ramos-Torrecillas, Olga García-Martínez, and Concepción Ruiz, “Repercussion of nonsteroidal anti-inflammatory drugs on the gene expression of human osteoblasts,” PeerJ, vol. 6, pp. e5415, 2018. View at Publisher · View at Google Scholar
  • Maria Cristina Aisa, Alessandro Datti, Antonio Orlacchio, and Gian Carlo Di Renzo, “COX inhibitors and bone: A safer impact on osteoblasts by NO-releasing NSAIDs,” Life Sciences, 2018. View at Publisher · View at Google Scholar
  • Francisco Javier Manzano-Moreno, Victor Javier Costela-Ruiz, Lucía Melguizo-Rodríguez, Rebeca Illescas-Montes, Olga García-Martínez, Concepción Ruiz, and Javier Ramos-Torrecillas, “INHIBITION OF VEGF GENE EXPRESSION IN OSTEOBLAST CELLS BY DIFFERENT NSAIDs,” Archives of Oral Biology, 2018. View at Publisher · View at Google Scholar
  • Javier Ramos-Torrecillas, Concepción Ruiz, Lucía Melguizo-Rodríguez, Ana Rivas, Olga García-Martínez, Francisco Javier Manzano-Moreno, and Elvira De Luna-Bertos, “Effect of olive oil phenolic compounds on osteoblast differentiation,” European Journal of Clinical Investigation, vol. 48, no. 4, 2018. View at Publisher · View at Google Scholar