The Scientific World Journal

Research Article

Therapeutic Doses of Nonsteroidal Anti-Inflammatory Drugs Inhibit Osteosarcoma MG-63 Osteoblast-Like Cells Maturation, Viability, and Biomineralization Potential

Table 5

Qualitative study of mineralization of MG63 cell line through formation of nodules, in relation to time, cultured in osteogenic medium supplemented with different NSAIDs: dexketoprofen, ketorolac, metamizole, and acetylsalicylic acid (1 and 10  M).
Treatment7 days15 days20 days
Number of nodulesSize of nodulesNumber of nodulesSize of nodulesNumber of nodulesSize of nodules
Control−−+40–80 µm++80–150 µm
Acetylsalicylic acid 1 µM−−±10–40 µm+50–100 µm
Acetylsalicylic acid 10 µM−−±10–40 µm+50–100 µm
Dexketoprofen 1 µM−−−−+50–100 µm
Dexketoprofen 10 µM−−−−−−
Ketorolac 1 µM−−−−+40–80 µm
Ketorolac 10 µM−−−−+40–80 µm
Metamizole 1 µM−−−−+10–40 µm
Metamizole 10 µM−−−−−−
− No detected nodules; ± of 0 to 10 nodules per well; + of 5 to 20 nodules per well; ++ more than 20 nodules per well.