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The Scientific World Journal
Volume 2013 (2013), Article ID 832789, 8 pages
http://dx.doi.org/10.1155/2013/832789
Research Article

Common and Specific Associations of Anti-SSA/Ro60 and Anti-Ro52/TRIM21 Antibodies in Systemic Lupus Erythematosus

1Department of Immunology, Hospital Universitario Central de Asturias, Celestino Villamil S/N, 33006 Oviedo, Spain
2Department of Internal Medicine, Hospital Universitario Central de Asturias, Celestino Villamil S/N, 33006 Oviedo, Spain
3Bone and Mineral Research Unit, Hospital Universitario Central de Asturias, Celestino Villamil S/N, 33006 Oviedo, Spain

Received 1 August 2013; Accepted 16 September 2013

Academic Editors: R. Cimaz, Y. Muro, and K. Tenbrock

Copyright © 2013 Aurora Menéndez et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Little information exists about the association of anti-SSA/Ro60 and anti-Ro52/TRIM21 with systemic lupus erytematosus (SLE) features. In this work, we analysed the associations of both anti-Ro reactivities with clinical and immunological manifestations in 141 SLE patients. Photosensitivity and xerophtalmia/xerostomia were found to be positively associated with both anti-SSA/Ro60 ( and , resp.) and anti-Ro52/TRIM21 ( and , resp.). In contrast, a negative association was detected regarding anti-phospholipid antibodies, anti-SSA/Ro60 having a stronger effect ( ) than anti-Ro52/TRIM21. Anti-SSA/Ro60 showed a specific positive association with hypocomplementemia ( ), mainly with low C4 levels ( ), whereas anti-Ro52/TRIM21 was found to be positively associated with Raynaud’s phenomenon ( ) and cytopenia ( ) and negatively associated with anti-dsDNA ( ). Lymphocytes are involved in the relationship between anti-Ro52/TRIM21 and cytopenia since positive patients showed lower cell levels than negative patients ( ). In conclusion, anti-SSA/Ro60 and anti-Ro52/TRIM21 showed both common and specific associations in SLE. These data thus increase evidence of the different associations of the two anti-Ro specificities even in a particular disease.