Isotretinoin Oil-Based Capsule Formulation Optimization

Figure 2

The three-dimensional contour diagrams illustrating the effect of beeswax (𝑋₁), hydrogenated coconut oil (𝑋₂), and soybean oil (𝑋₃) on the isotretinoin release percentage at 10 min (a), 30 min (b), 60 min (c), and 90 min (d).

(a)

(b)

(c)

(d)