Isotretinoin Oil-Based Capsule Formulation Optimization

Table 1

Summary of variables for the mixture design.

Causal factors variables	Code (amount)
	Low	High
𝑋1: beeswax	0 (8)	0.166 (12)
𝑋2: hydrogenated coconut oil	0 (20)	0.834 (40)
𝑋3: soybean oil	0 (96)	1.000 (120)
Response variables	Constraints
𝑌10min: percent dissolved in 10 min	0%≤𝑌1≤15%
𝑌30min: percent dissolved in 4 h	15%≤𝑌2≤40%
𝑌60min: percent dissolved in 8 h	70%≤𝑌3≤85%
𝑌90min: percent dissolved in 14 h	85%≤𝑌4≤100%

(1) The total amount of isotretinoin oil-based capsule was 160 mg composed of isotretinoin 10 mg, vitamin E 2 mg, and other ingredients 148 mg including beeswax (𝑋₁), hydrogenated coconut oil (𝑋₂), and soybean oil (𝑋₃).
(2) 𝑋₁+𝑋₂+𝑋₃=148mg = 100%.